Risk of lung cancer in patients with HL according to type of treatment and smoking category
| Treatment of Hodgkin disease . | RR (95% CI) by smoking category (# of case patients; control patient)* . | ||
|---|---|---|---|
| Radiation ≥5 Gy . | Alkylating agents . | Non-smoker, light, other† . | Moderate-heavy‡ . |
| No | No | 1.0§ | 6.0 (1.9-20.4) |
| Yes | No | 7.2 (2.9-21.2) | 20.2 (6.8-68) |
| No | Yes | 4.3 (1.8-11.7) | 16.8 (6.2-53) |
| Yes | Yes | 7.2 (2.8-21.6) | 49.1 (15.1-187) |
| Treatment of Hodgkin disease . | RR (95% CI) by smoking category (# of case patients; control patient)* . | ||
|---|---|---|---|
| Radiation ≥5 Gy . | Alkylating agents . | Non-smoker, light, other† . | Moderate-heavy‡ . |
| No | No | 1.0§ | 6.0 (1.9-20.4) |
| Yes | No | 7.2 (2.9-21.2) | 20.2 (6.8-68) |
| No | Yes | 4.3 (1.8-11.7) | 16.8 (6.2-53) |
| Yes | Yes | 7.2 (2.8-21.6) | 49.1 (15.1-187) |
Adapted from Travis et al.31
*Represents estimated tobacco smoking habit 5 years before diagnosis date of lung cancer and corresponding date in control patients, with the use of information recorded up to 1 year before these dates.
†This group includes nonsmokers, light current cigarette smokers (<1 pack per day), former cigarette smokers, smokers of cigar and pipes only, and patients from whom tobacco smoking habit was not stated.
‡Moderate (1 to 2 packs per day) and heavy (>2 packs per day) current cigarette smokers.
§Reference group.