Results from subgroup-specific case-case analysis of association between ALL risk alleles and DS status
| SNP . | Position . | Gene . | CRLF2-high (151 DS-ALL, 55 non-DS ALL) . | High hyperdiploid (19 DS-ALL, 888 non-DS ALL) . | ETV6-RUNX1 (45 DS-ALL, 547 non-DS ALL) . | B-other (40 DS-ALL, 859 non-DS ALL) . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) . | P . | OR (95% CI) . | P . | OR (95% CI) . | P . | OR (95% CI) . | P . | |||
| rs11978267 | Chr7:50466304 | IKZF1 | 0.71 (0.48-1.05) | .08 | 1.26 (0.67-2.36) | .47 | 0.89 (0.55-1.45) | .65 | 1.37 (0.87-2.17) | .17 |
| rs3731249 | Chr9:21970916 | CDKN2A | 2.16 (0.96-4.89) | .06 | 1.62 (0.49-5.43) | .43 | 1.68 (0.64-4.39) | .29 | 1.49 (0.60-3.68) | .39 |
| rs3824662 | Chr10:8104208 | GATA3 | 0.73 (0.50-1.06) | .10 | 1.02 (0.48-2.20) | .95 | 1.02 (0.59-1.78) | .94 | 0.74 (0.42-1.29) | .29 |
| rs12769953 | Chr10:22407656 | BMI1 | 1.28 (0.78-2.11) | .33 | 1.52 (0.58-3.95) | .40 | 0.75 (0.45-1.22) | .24 | 1.45 (0.76-2.77) | .26 |
| rs10741006 | Chr10:22856019 | PIP4K2A | 0.85 (0.56-1.31) | .47 | 0.75 (0.38-1.48) | .41 | 0.78 (0.49-1.23) | .28 | 1.73 (1.00-2.97) | .04 |
| rs7089424 | Chr10:63752159 | ARID5B | 0.45 (0.30-0.67) | 1.0e-4 | 1.38 (0.70-2.74) | .36 | 1.02 (0.65-1.61) | .93 | 1.06 (0.68-1.66) | .80 |
| rs2239633 | Chr14:23589057 | CEBPE | 1.35 (0.93-1.98) | .12 | 0.92 (0.47-1.80) | .81 | 1.19 (0.76-1.88) | .45 | 1.01 (0.62-1.63) | .99 |
| SNP . | Position . | Gene . | CRLF2-high (151 DS-ALL, 55 non-DS ALL) . | High hyperdiploid (19 DS-ALL, 888 non-DS ALL) . | ETV6-RUNX1 (45 DS-ALL, 547 non-DS ALL) . | B-other (40 DS-ALL, 859 non-DS ALL) . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) . | P . | OR (95% CI) . | P . | OR (95% CI) . | P . | OR (95% CI) . | P . | |||
| rs11978267 | Chr7:50466304 | IKZF1 | 0.71 (0.48-1.05) | .08 | 1.26 (0.67-2.36) | .47 | 0.89 (0.55-1.45) | .65 | 1.37 (0.87-2.17) | .17 |
| rs3731249 | Chr9:21970916 | CDKN2A | 2.16 (0.96-4.89) | .06 | 1.62 (0.49-5.43) | .43 | 1.68 (0.64-4.39) | .29 | 1.49 (0.60-3.68) | .39 |
| rs3824662 | Chr10:8104208 | GATA3 | 0.73 (0.50-1.06) | .10 | 1.02 (0.48-2.20) | .95 | 1.02 (0.59-1.78) | .94 | 0.74 (0.42-1.29) | .29 |
| rs12769953 | Chr10:22407656 | BMI1 | 1.28 (0.78-2.11) | .33 | 1.52 (0.58-3.95) | .40 | 0.75 (0.45-1.22) | .24 | 1.45 (0.76-2.77) | .26 |
| rs10741006 | Chr10:22856019 | PIP4K2A | 0.85 (0.56-1.31) | .47 | 0.75 (0.38-1.48) | .41 | 0.78 (0.49-1.23) | .28 | 1.73 (1.00-2.97) | .04 |
| rs7089424 | Chr10:63752159 | ARID5B | 0.45 (0.30-0.67) | 1.0e-4 | 1.38 (0.70-2.74) | .36 | 1.02 (0.65-1.61) | .93 | 1.06 (0.68-1.66) | .80 |
| rs2239633 | Chr14:23589057 | CEBPE | 1.35 (0.93-1.98) | .12 | 0.92 (0.47-1.80) | .81 | 1.19 (0.76-1.88) | .45 | 1.01 (0.62-1.63) | .99 |
Analyses comparing DS-ALL and non-DS ALL cases enrolled on COG P9900 or AALL0232 trials. P values and ORs calculated using logistic regression tests assuming additive allelic effects, adjusting for the top 5 principal components.