Results from case-case analysis of association between ALL risk alleles and DS status
| SNP . | Pos . | Gene . | DS-ALL CCRLP comparison* (567 DS-ALL, 3083 non-DS ALL) . | DS-ALL COG comparison† (255 DS-ALL, 2387 non-DS ALL) . | DS-ALL COG molecular subgroup adjusted comparison‡ (255 DS-ALL, 2387 non-DS ALL) . | |||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) . | P . | OR (95% CI) . | P . | OR (95% CI) . | P . | |||
| rs11978267 | Chr7:50466304 | IKZF1 | 1.18 (1.03-1.36) | .015 | 1.15 (0.95-1.39) | .154 | 0.97 (0.77-1.23) | .820 |
| rs3731249 | Chr9:21970916 | CDKN2A | 1.58 (1.23-2.03) | 4.08e-4 | 1.80 (1.27-2.55) | .001 | 1.72 (1.10-2.69) | .017 |
| rs3824662 | Chr10:8104208 | GATA3 | 1.34 (1.16-1.54) | 4.38e-5 | 1.34 (1.09-1.64) | .006 | 0.81 (0.63-1.06) | .121 |
| rs12769953 | Chr10:22407656 | BMI1 | 1.17 (0.98-1.39) | .077 | 1.12 (0.88-1.43) | .343 | 1.12 (0.83-1.50) | .461 |
| rs10741006 | Chr10:22856019 | PIP4K2A | 1.15 (0.99-1.34) | .074 | 1.04 (0.85-1.28) | .691 | 0.96 (0.75-1.23) | .759 |
| rs7089424 | Chr10:63752159 | ARID5B | 0.98 (0.85-1.11) | .71 | 0.77 (0.64-0.93) | .006 | 0.80 (0.64-1.01) | .056 |
| rs2239633 | Chr14:23589057 | CEBPE | 1.15 (1.01-1.32) | .043 | 1.15 (0.94-1.40) | .167 | 1.17 (0.92-1.47) | .199 |
| SNP . | Pos . | Gene . | DS-ALL CCRLP comparison* (567 DS-ALL, 3083 non-DS ALL) . | DS-ALL COG comparison† (255 DS-ALL, 2387 non-DS ALL) . | DS-ALL COG molecular subgroup adjusted comparison‡ (255 DS-ALL, 2387 non-DS ALL) . | |||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) . | P . | OR (95% CI) . | P . | OR (95% CI) . | P . | |||
| rs11978267 | Chr7:50466304 | IKZF1 | 1.18 (1.03-1.36) | .015 | 1.15 (0.95-1.39) | .154 | 0.97 (0.77-1.23) | .820 |
| rs3731249 | Chr9:21970916 | CDKN2A | 1.58 (1.23-2.03) | 4.08e-4 | 1.80 (1.27-2.55) | .001 | 1.72 (1.10-2.69) | .017 |
| rs3824662 | Chr10:8104208 | GATA3 | 1.34 (1.16-1.54) | 4.38e-5 | 1.34 (1.09-1.64) | .006 | 0.81 (0.63-1.06) | .121 |
| rs12769953 | Chr10:22407656 | BMI1 | 1.17 (0.98-1.39) | .077 | 1.12 (0.88-1.43) | .343 | 1.12 (0.83-1.50) | .461 |
| rs10741006 | Chr10:22856019 | PIP4K2A | 1.15 (0.99-1.34) | .074 | 1.04 (0.85-1.28) | .691 | 0.96 (0.75-1.23) | .759 |
| rs7089424 | Chr10:63752159 | ARID5B | 0.98 (0.85-1.11) | .71 | 0.77 (0.64-0.93) | .006 | 0.80 (0.64-1.01) | .056 |
| rs2239633 | Chr14:23589057 | CEBPE | 1.15 (1.01-1.32) | .043 | 1.15 (0.94-1.40) | .167 | 1.17 (0.92-1.47) | .199 |