Association between published ALL susceptibility loci and CRLF2 overexpression status in children with DS
| SNP . | Chr . | Pos . | Gene . | CRLF2 overexpression (114 DS-ALL cases, 769 DS controls) . | No CRLF2 overexpression (104 DS-ALL cases, 769 DS controls) . | ||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) . | P . | Direction* . | OR (95% CI) . | P . | Direction* . | ||||
| rs11978267 | 7 | 50466304 | IKZF1 | 2.04 (1.51-2.76) | 3.02e-6 | +++ | 1.93 (1.41-2.64) | 4.37e-5 | +++ |
| rs3731249 | 9 | 21970916 | CDKN2A | 4.27 (2.36-7.71) | 1.49e-6 | +++ | 3.38 (1.71-6.71) | 4.85e-4 | ++− |
| rs3824662 | 10 | 8104208 | GATA3 | 1.72 (1.26-2.35) | 5.97e-4 | +++ | 1.40 (0.99-1.96) | 0.051 | +++ |
| rs12769953 | 10 | 22407656 | BMI1 | 1.45 (0.98-2.14) | 0.061 | +++ | 1.26 (0.85-1.86) | 0.25 | +−+ |
| rs10741006 | 10 | 22856019 | PIP4K2A | 1.27 (0.93-1.71) | 0.13 | +++ | 1.67 (1.17-2.36) | 4.25e-3 | +++ |
| rs7089424 | 10 | 63752159 | ARID5B | 1.07 (0.80-1.45) | 0.64 | −++ | 2.32 (1.68-3.20) | 2.95e-7 | +++ |
| rs2239633 | 14 | 23589057 | CEBPE | 1.46 (1.07-1.98) | 0.017 | +++ | 1.18 (0.85-1.64) | 0.31 | +−− |
| SNP . | Chr . | Pos . | Gene . | CRLF2 overexpression (114 DS-ALL cases, 769 DS controls) . | No CRLF2 overexpression (104 DS-ALL cases, 769 DS controls) . | ||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) . | P . | Direction* . | OR (95% CI) . | P . | Direction* . | ||||
| rs11978267 | 7 | 50466304 | IKZF1 | 2.04 (1.51-2.76) | 3.02e-6 | +++ | 1.93 (1.41-2.64) | 4.37e-5 | +++ |
| rs3731249 | 9 | 21970916 | CDKN2A | 4.27 (2.36-7.71) | 1.49e-6 | +++ | 3.38 (1.71-6.71) | 4.85e-4 | ++− |
| rs3824662 | 10 | 8104208 | GATA3 | 1.72 (1.26-2.35) | 5.97e-4 | +++ | 1.40 (0.99-1.96) | 0.051 | +++ |
| rs12769953 | 10 | 22407656 | BMI1 | 1.45 (0.98-2.14) | 0.061 | +++ | 1.26 (0.85-1.86) | 0.25 | +−+ |
| rs10741006 | 10 | 22856019 | PIP4K2A | 1.27 (0.93-1.71) | 0.13 | +++ | 1.67 (1.17-2.36) | 4.25e-3 | +++ |
| rs7089424 | 10 | 63752159 | ARID5B | 1.07 (0.80-1.45) | 0.64 | −++ | 2.32 (1.68-3.20) | 2.95e-7 | +++ |
| rs2239633 | 14 | 23589057 | CEBPE | 1.46 (1.07-1.98) | 0.017 | +++ | 1.18 (0.85-1.64) | 0.31 | +−− |
Direction of risk allele effects for COG/NDSP study 1 European samples, COG/NDSP study 2 European samples, and COG/NDSP study 2 Hispanic samples.