Familial relative risks for all hematological malignancy, NHL, CLL, myeloid malignancy, and myeloproliferative neoplasm, stratified by number of affected first-degree relatives
| . | Population CR (%) . | Number of FDRs . | ||||||
|---|---|---|---|---|---|---|---|---|
| 1 affected FDR . | ≥2 affected FDR . | P value . | ||||||
| N . | SIR (95% CI) . | CR (%) . | N . | SIR (95% CI) . | CR (%) . | |||
| All hematological malignancies | 3.4 | 5941 | 1.31 (1.28-1.34) | 4.2 | 279 | 2.08 (1.84-2.33) | 7.4 | 2.1 × 10−12 |
| NHL | 1.3 | 1165 | 1.75 (1.65-1.85) | 2.1 | 19 | 2.06 (1.24-3.22) | 2.4 | .50 |
| CLL | 0.4 | 297 | 5.36 (4.77-6.00) | 2.1 | 20 | 27.13 (16.97-42.90) | 8.6 | 1.34 × 10−8 |
| Myeloid malignancies | 0.7 | 470 | 1.96 (1.79-2.15) | 1.4 | 9 | 4.55 (2.08-8.64) | 4.4 | .02 |
| MPN | 0.3 | 176 | 4.83 (4.14-5.60) | 1.2 | 5 | 17.82 (5.79-24.89) | 3.2 | .01 |
| . | Population CR (%) . | Number of FDRs . | ||||||
|---|---|---|---|---|---|---|---|---|
| 1 affected FDR . | ≥2 affected FDR . | P value . | ||||||
| N . | SIR (95% CI) . | CR (%) . | N . | SIR (95% CI) . | CR (%) . | |||
| All hematological malignancies | 3.4 | 5941 | 1.31 (1.28-1.34) | 4.2 | 279 | 2.08 (1.84-2.33) | 7.4 | 2.1 × 10−12 |
| NHL | 1.3 | 1165 | 1.75 (1.65-1.85) | 2.1 | 19 | 2.06 (1.24-3.22) | 2.4 | .50 |
| CLL | 0.4 | 297 | 5.36 (4.77-6.00) | 2.1 | 20 | 27.13 (16.97-42.90) | 8.6 | 1.34 × 10−8 |
| Myeloid malignancies | 0.7 | 470 | 1.96 (1.79-2.15) | 1.4 | 9 | 4.55 (2.08-8.64) | 4.4 | .02 |
| MPN | 0.3 | 176 | 4.83 (4.14-5.60) | 1.2 | 5 | 17.82 (5.79-24.89) | 3.2 | .01 |
P represents a trend test. Data on the clonal myeloid neoplasms have previously been reported.18
CR, cumulative risk.