Table 3. Univariate and multivariate... | American Society of Hematology

Table 3.

Univariate and multivariate analyses

End points and model variables	Univariate analysis					Multivariate analysis
End points and model variables	HR	OR	95% CI		P	HR	OR	95% CI		P
CHR
ISAPL modeling: high vs low	—	0.26	0.17	0.66	.002	—	0.22	0.1	0.6	.003
Relapse-risk group: low vs intermediate vs high	—	0.67	0.39	0.86	.006	—	0.88	0.45	1.69	.705
Age at diagnosis: continuous variable	—	0.4	0.2	0.79	.008	—	0.39	0.2	0.78	.008
OS
ISAPL modeling: high vs low	5.1	—	2.22	11.6	<.001	6.1	—	2.46	15.4	<.001
Relapse-risk group: low vs intermediate vs high	2.86	—	1.75	4.66	<.001	1.91	—	1.1	3.41	.027
Age at diagnosis: continuous variable	1.5	—	1.05	2.26	.047	2.4	—	1.36	4.22	.002
DFS
ISAPL modeling: high vs low	2.86	—	1.1	7.88	.04	2.19	—	1.77	6.23	.038
Relapse-risk group: low vs intermediate vs high	3.25	—	1.51	7	.003	2.89	—	1.14	7.27	.024
Age at diagnosis: continuous variable	1.14	—	0.57	2.28	0.704	1.14	—	0.45	2.89	.78
EFS
ISAPL modeling: high vs low	3.96	—	2.05	7.65	<.001	4.05	—	2	8.19	<.001
Relapse-risk group: low vs intermediate vs high	2.69	—	1.77	4.1	<.001	1.93	—	1.17	3.18	.009
Age at diagnosis: continuous variable	1.34	—	0.93	1.93	.105	1.77	—	1.1	2.9	.02

End points and model variables	Univariate analysis					Multivariate analysis
End points and model variables	HR	OR	95% CI		P	HR	OR	95% CI		P
CHR
ISAPL modeling: high vs low	—	0.26	0.17	0.66	.002	—	0.22	0.1	0.6	.003
Relapse-risk group: low vs intermediate vs high	—	0.67	0.39	0.86	.006	—	0.88	0.45	1.69	.705
Age at diagnosis: continuous variable	—	0.4	0.2	0.79	.008	—	0.39	0.2	0.78	.008
OS
ISAPL modeling: high vs low	5.1	—	2.22	11.6	<.001	6.1	—	2.46	15.4	<.001
Relapse-risk group: low vs intermediate vs high	2.86	—	1.75	4.66	<.001	1.91	—	1.1	3.41	.027
Age at diagnosis: continuous variable	1.5	—	1.05	2.26	.047	2.4	—	1.36	4.22	.002
DFS
ISAPL modeling: high vs low	2.86	—	1.1	7.88	.04	2.19	—	1.77	6.23	.038
Relapse-risk group: low vs intermediate vs high	3.25	—	1.51	7	.003	2.89	—	1.14	7.27	.024
Age at diagnosis: continuous variable	1.14	—	0.57	2.28	0.704	1.14	—	0.45	2.89	.78
EFS
ISAPL modeling: high vs low	3.96	—	2.05	7.65	<.001	4.05	—	2	8.19	<.001
Relapse-risk group: low vs intermediate vs high	2.69	—	1.77	4.1	<.001	1.93	—	1.17	3.18	.009
Age at diagnosis: continuous variable	1.34	—	0.93	1.93	.105	1.77	—	1.1	2.9	.02

HRs and ORs >1 or <1 indicate an increased or decreased risk, respectively, of an event for the first category listed. Relapse-risk group: classification according to PETHEMA/GIMEMA criteria.⁶

DFS, disease-free survival; EFS, event-free survival.

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