Clinical data of the BCP-ALL in 2 individuals with the t(12;14)(p13.2;q23.1)
| Patient . | Age at dx, y . | Karyotype based on SNP array . | WBC*, ×109/L . | Blast cells in PB at dx, % . | Blast cells in BM at dx, % . | Treatment protocol . | Events . | Severe adverse effects . |
|---|---|---|---|---|---|---|---|---|
| III:3 | 8 | 57,XX,t(12;14)(p13.2;q23.1), +X,+X,+6,+10, +der(14)t(12;14)(p13.2;q23.1), +14,+17,+18,+18,+21,+21 | 2.8 | 0 | 95 | NOPHO-ALL1992-HR | No | Osteonecrosis |
| IV:2 | 12 | 54,XX,t(12;14)(p13.2;q23.1), +X,+4,+6, +der(14)t(12;14)(p13.2;q23.1), +17,+18,+21,+21 | 4.4 | 10 | 95 | NOPHO-ALL2008-SR | No | Osteonecrosis, vincristine neuropathy, osteoporosis, compression fractures |
| Patient . | Age at dx, y . | Karyotype based on SNP array . | WBC*, ×109/L . | Blast cells in PB at dx, % . | Blast cells in BM at dx, % . | Treatment protocol . | Events . | Severe adverse effects . |
|---|---|---|---|---|---|---|---|---|
| III:3 | 8 | 57,XX,t(12;14)(p13.2;q23.1), +X,+X,+6,+10, +der(14)t(12;14)(p13.2;q23.1), +14,+17,+18,+18,+21,+21 | 2.8 | 0 | 95 | NOPHO-ALL1992-HR | No | Osteonecrosis |
| IV:2 | 12 | 54,XX,t(12;14)(p13.2;q23.1), +X,+4,+6, +der(14)t(12;14)(p13.2;q23.1), +17,+18,+21,+21 | 4.4 | 10 | 95 | NOPHO-ALL2008-SR | No | Osteonecrosis, vincristine neuropathy, osteoporosis, compression fractures |
BM, bone marrow; dx, diagnosis; HR, high-risk NOPHO-ALL protocol; PB, peripheral blood; SR, standard-risk NOPHO-ALL protocol; WBC, white blood cell count.
The highest value (109/L) at diagnosis.