Regression estimates for hemoglobin increment in the initial posttransfusion period (n = 38 019)
| Characteristic . | Change in hemoglobin (95% CI) . | P . |
|---|---|---|
| Male donor | 0.10 (0.08 to 0.12) | <.01 |
| Donor age (reference, <20 y) | ||
| 20-45 | 0.00 (–0.03 to 0.03) | .95 |
| 45-70 | 0.00 (–0.02 to 0.03) | .81 |
| >70 | −0.03 (–0.08 to 0.01) | .14 |
| Donor Rh-positive status | 0.00 (–0.04 to 0.03) | .86 |
| Donor ABO status (ref: non-O) | ||
| Blood type O | −0.01 (–0.07 to 0.04) | .65 |
| Whole blood collection | 0.16 (0.13 to 0.18) | <.001 |
| Storage duration (ref: 1-21 d) | ||
| 22-28 | −0.00 (–0.03 to 0.03) | .41 |
| 29-35 | −0.00 (–0.02 to 0.01) | .73 |
| 36-42 | −0.02 (–0.04 to 0.01) | .27 |
| RBC additive solution (reference, AS-1)* | ||
| AS-3 | −0.07 (–0.12 to −0.02) | .01 |
| Gamma irradiation | −0.06 (–0.10 to −0.02) | .002 |
| Female recipient | 0.28 (0.26 to 0.29) | <.001 |
| Recipient age† | 0.04 (0.04 to 0.05) | <.001 |
| Recipient BMI | −0.02 (–0.02 to −0.02) | <.001 |
| Recipient Rh-positive status | 0.06 (0.01 to 0.10) | .01 |
| Recipient ABO status (reference, non-O) | ||
| Blood type O | 0.01 (–0.06 to 0.08) | .87 |
| Pre-transfusion Hb level | −0.18 (–0.20 to −0.17) | <.001 |
| Hours between pre-Tx measurement and Tx | 0.01 (0.01 to 0.01) | <.001 |
| Hours between Tx and post-Tx measurement | 0.01 (0.01 to 0.01) | <.001 |
| Tx year | −0.02 (–0.02 to −0.01) | <.001 |
| Characteristic . | Change in hemoglobin (95% CI) . | P . |
|---|---|---|
| Male donor | 0.10 (0.08 to 0.12) | <.01 |
| Donor age (reference, <20 y) | ||
| 20-45 | 0.00 (–0.03 to 0.03) | .95 |
| 45-70 | 0.00 (–0.02 to 0.03) | .81 |
| >70 | −0.03 (–0.08 to 0.01) | .14 |
| Donor Rh-positive status | 0.00 (–0.04 to 0.03) | .86 |
| Donor ABO status (ref: non-O) | ||
| Blood type O | −0.01 (–0.07 to 0.04) | .65 |
| Whole blood collection | 0.16 (0.13 to 0.18) | <.001 |
| Storage duration (ref: 1-21 d) | ||
| 22-28 | −0.00 (–0.03 to 0.03) | .41 |
| 29-35 | −0.00 (–0.02 to 0.01) | .73 |
| 36-42 | −0.02 (–0.04 to 0.01) | .27 |
| RBC additive solution (reference, AS-1)* | ||
| AS-3 | −0.07 (–0.12 to −0.02) | .01 |
| Gamma irradiation | −0.06 (–0.10 to −0.02) | .002 |
| Female recipient | 0.28 (0.26 to 0.29) | <.001 |
| Recipient age† | 0.04 (0.04 to 0.05) | <.001 |
| Recipient BMI | −0.02 (–0.02 to −0.02) | <.001 |
| Recipient Rh-positive status | 0.06 (0.01 to 0.10) | .01 |
| Recipient ABO status (reference, non-O) | ||
| Blood type O | 0.01 (–0.06 to 0.08) | .87 |
| Pre-transfusion Hb level | −0.18 (–0.20 to −0.17) | <.001 |
| Hours between pre-Tx measurement and Tx | 0.01 (0.01 to 0.01) | <.001 |
| Hours between Tx and post-Tx measurement | 0.01 (0.01 to 0.01) | <.001 |
| Tx year | −0.02 (–0.02 to −0.01) | <.001 |
Pretransfusion Hb level within 18 hours of transfusion (Tx) and change in Hb within 18-hour period after Tx. Hb changes are given in grams per deciliter. CI, confidence interval.
Regression estimates for other storage solutions included in appendix tables.
Coefficient for recipient age corresponds to change in mean outcome associated with 10-year increase.