Table 2

Frequencies of MLD in 1766 patients correlated with age, cytogenetic risk groups, NPM1/FLT3-ITD mutations, and history of AML

All patients (n = 1766) MLD (%)P
Age (≤ 60 vs > 60 years) 28.7 vs 30.4 NS (.4) 
Cytogenetic risk group (favorable/intermediate/unfavorable) 13.0/28.3/41.6 < .001 
FLT3-ITD* (negative vs positive) 34.1 vs 24.0 < .001 
NPM1 (wild type vs mutation) 31.5 vs 30.2 NS (.7) 
History of AML (de novo vs secondary) 25.2 vs 45.4 < .001 
All patients (n = 1766) MLD (%)P
Age (≤ 60 vs > 60 years) 28.7 vs 30.4 NS (.4) 
Cytogenetic risk group (favorable/intermediate/unfavorable) 13.0/28.3/41.6 < .001 
FLT3-ITD* (negative vs positive) 34.1 vs 24.0 < .001 
NPM1 (wild type vs mutation) 31.5 vs 30.2 NS (.7) 
History of AML (de novo vs secondary) 25.2 vs 45.4 < .001 

MLD indicates multilineage dysplasia according to WHO classification; NS, not significant.

*

Data available in 1237 patients.

Data available in 1209 patients.

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