Table 1

Makeup of T-cell grafts transferred into BM transplant recipients

BM transplant recipientsThy1.1+/+Thy1.1+/Thy1.2+Phenotype
Tregs only 1.5 × 105 1.5 × 105 CFSElowGITR+ 
Teffs only 1.5 × 105 1.5 × 105 CFSElowGITR− 
Tregs + Teffs 1.5 × 105 0 CFSElowGITR+ 
Tregs + Teffs 0 1.5 × 105 CFSElowGITR− 
BM transplant recipientsThy1.1+/+Thy1.1+/Thy1.2+Phenotype
Tregs only 1.5 × 105 1.5 × 105 CFSElowGITR+ 
Teffs only 1.5 × 105 1.5 × 105 CFSElowGITR− 
Tregs + Teffs 1.5 × 105 0 CFSElowGITR+ 
Tregs + Teffs 0 1.5 × 105 CFSElowGITR− 

On the day of HSCT, recipients received 850 cGy TBI and received 4 × 106 T cell–depleted BM cells along with 300 000 sorted Tregs and/or Teffs on different Thyl congenic backgrounds.

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