Makeup of T-cell grafts transferred into BM transplant recipients
| BM transplant recipients . | Thy1.1+/+ . | Thy1.1+/Thy1.2+ . | Phenotype . |
|---|---|---|---|
| Tregs only | 1.5 × 105 | 1.5 × 105 | CFSElowGITR+ |
| Teffs only | 1.5 × 105 | 1.5 × 105 | CFSElowGITR− |
| Tregs + Teffs | 1.5 × 105 | 0 | CFSElowGITR+ |
| Tregs + Teffs | 0 | 1.5 × 105 | CFSElowGITR− |
| BM transplant recipients . | Thy1.1+/+ . | Thy1.1+/Thy1.2+ . | Phenotype . |
|---|---|---|---|
| Tregs only | 1.5 × 105 | 1.5 × 105 | CFSElowGITR+ |
| Teffs only | 1.5 × 105 | 1.5 × 105 | CFSElowGITR− |
| Tregs + Teffs | 1.5 × 105 | 0 | CFSElowGITR+ |
| Tregs + Teffs | 0 | 1.5 × 105 | CFSElowGITR− |
On the day of HSCT, recipients received 850 cGy TBI and received 4 × 106 T cell–depleted BM cells along with 300 000 sorted Tregs and/or Teffs on different Thyl congenic backgrounds.