Summary statistics of SGN-30 pharmacokinetic parameters following first and last infusion in patients with refractory or recurrent CD30+ hematologic malignancies
| Dose group, mg/kg . | Cmax, μg/mL . | AUCtau, μg*d/mL . | Cmind7, μg/mL . | AIAUC* . | AICmax* . | AICmin* . |
|---|---|---|---|---|---|---|
| Cycle 1 | ||||||
| 2, n = 6 | 46.1 (31) | 185.9 (17) | 16.91 (21) | NA | NA | NA |
| 4, n = 6 | 89.1 (19) | 366.1 (22) | 33.97 (20) | NA | NA | NA |
| 8, n = 5 | 181.5 (16) | 705.5 (21) | 68.61 (24) | NA | NA | NA |
| 12, n = 4 | 265.0 (28) | 1123 (18) | 107.1 (21) | NA | NA | NA |
| Cycle 6 | ||||||
| 2, n = 4 | 100.5 (26) | 525.7 (29) | 57.58 (36) | 2.6 (34) | 2.0 (32) | 3.0 (41) |
| 4, n = 4 | 200.2 (25) | 991.6 (36) | 115.2 (38) | 2.6 (31) | 2.2 (17) | 3.2 (27) |
| 8, n = 4 | 265.2 (13) | 1324 (32) | 130.9 (43) | 2.0 (49) | 1.5 (17) | 2.0 (57) |
| 12, n = 4 | 592.3 (27) | 3381 (25) | 397.9 (31) | 2.7 (19) | 2.0 (8) | 3.5 (29) |
| Dose group, mg/kg . | Cmax, μg/mL . | AUCtau, μg*d/mL . | Cmind7, μg/mL . | AIAUC* . | AICmax* . | AICmin* . |
|---|---|---|---|---|---|---|
| Cycle 1 | ||||||
| 2, n = 6 | 46.1 (31) | 185.9 (17) | 16.91 (21) | NA | NA | NA |
| 4, n = 6 | 89.1 (19) | 366.1 (22) | 33.97 (20) | NA | NA | NA |
| 8, n = 5 | 181.5 (16) | 705.5 (21) | 68.61 (24) | NA | NA | NA |
| 12, n = 4 | 265.0 (28) | 1123 (18) | 107.1 (21) | NA | NA | NA |
| Cycle 6 | ||||||
| 2, n = 4 | 100.5 (26) | 525.7 (29) | 57.58 (36) | 2.6 (34) | 2.0 (32) | 3.0 (41) |
| 4, n = 4 | 200.2 (25) | 991.6 (36) | 115.2 (38) | 2.6 (31) | 2.2 (17) | 3.2 (27) |
| 8, n = 4 | 265.2 (13) | 1324 (32) | 130.9 (43) | 2.0 (49) | 1.5 (17) | 2.0 (57) |
| 12, n = 4 | 592.3 (27) | 3381 (25) | 397.9 (31) | 2.7 (19) | 2.0 (8) | 3.5 (29) |
Pharmacokinetic parameter data are summarized as geometric means (%CV).
NA indicates not applicable. AI indicates accumulation index, calculated as ratio of respective parameter value between cycle 6 and cycle 1.