DNC subjects who had “high risk” early predictors
| Early predictors . | Subjects, N (%) . |
|---|---|
| Individual predictors | |
| Early dactylitis* | 29 (17.3) |
| Severe anemia† | 5 (2.9) |
| Leukocytosis‡ | 20 (11.9) |
| “High risk” combinations§ | |
| Early dactylitis and severe anemia | 0 |
| Early dactylitis and leukocytosis | 3 (2.5) |
| Severe anemia and leukocytosis | 1 (0.5) |
| Early predictors . | Subjects, N (%) . |
|---|---|
| Individual predictors | |
| Early dactylitis* | 29 (17.3) |
| Severe anemia† | 5 (2.9) |
| Leukocytosis‡ | 20 (11.9) |
| “High risk” combinations§ | |
| Early dactylitis and severe anemia | 0 |
| Early dactylitis and leukocytosis | 3 (2.5) |
| Severe anemia and leukocytosis | 1 (0.5) |
Dactylitis before 1 year of age.
Mean hemoglobin concentration less than or equal to 7 g/dL in second year of life.
Mean leukocyte count of 20 000 /mm3 or greater in second year of life.
Combinations associated with a high probability (≥ 0.36) of severe disease by 10 years of age in the CSSCD infant cohort.