Distribution of prognostic factors in CLL cases according to CD49d expression
| Parameter, category* . | CD49d, no. . | P(χ2)† . | ρ‡ . | n§ . | 10-year survival, % . | 10-year untreated, % . | |
|---|---|---|---|---|---|---|---|
| Less than 30% . | More than 30% . | ||||||
| CD38 | |||||||
| Less than 30% | 153 | 45 | < .001 | 0.59 | 303 | 88 | 40 |
| More than or equal to 30% | 20 | 85 | — | — | — | 65¶ | 15¶ |
| IGHV | |||||||
| M | 98 | 45 | < .001 | 0.34 | 210 | 87 | 41 |
| UM | 22 | 45 | — | — | — | 43¶ | 9¶ |
| ZAP-70 | |||||||
| Less than 20% | 107 | 49 | < .001 | 0.26 | 270 | 95 | 44 |
| More than or equal to 20% | 49 | 65 | — | — | — | 79¶ | 17¶ |
| sCD23 | |||||||
| Less than 70 IU | 89 | 49 | .001 | 0.22 | 206 | 98 | 46 |
| More than or equal to 70 IU | 28 | 40 | — | — | — | 84¶ | 7¶ |
| mod-Rai | |||||||
| I | 73 | 32 | .002 | 0.18 | 292 | 97 | 53 |
| II-III | 96 | 91 | — | — | — | 91 | 19¶ |
| FISH | |||||||
| Normal‖ | 30 | 45 | .18 | 0.11 | 156 | NT | 46 |
| Abnormal | 41 | 40 | — | — | — | NT | 15¶ |
| β2M | |||||||
| Less than 2.2 g/L | 84 | 51 | .10 | 0.11 | 232 | 97 | 45 |
| More than or equal to 2.2 g/L | 50 | 47 | — | — | — | 88¶ | 14¶ |
| Age | |||||||
| Less than 65 years | 94 | 65 | .49 | 0.04 | 302 | 86 | 28 |
| More than or equal to 65 years | 79 | 64 | — | — | — | 73¶ | 35 |
| Parameter, category* . | CD49d, no. . | P(χ2)† . | ρ‡ . | n§ . | 10-year survival, % . | 10-year untreated, % . | |
|---|---|---|---|---|---|---|---|
| Less than 30% . | More than 30% . | ||||||
| CD38 | |||||||
| Less than 30% | 153 | 45 | < .001 | 0.59 | 303 | 88 | 40 |
| More than or equal to 30% | 20 | 85 | — | — | — | 65¶ | 15¶ |
| IGHV | |||||||
| M | 98 | 45 | < .001 | 0.34 | 210 | 87 | 41 |
| UM | 22 | 45 | — | — | — | 43¶ | 9¶ |
| ZAP-70 | |||||||
| Less than 20% | 107 | 49 | < .001 | 0.26 | 270 | 95 | 44 |
| More than or equal to 20% | 49 | 65 | — | — | — | 79¶ | 17¶ |
| sCD23 | |||||||
| Less than 70 IU | 89 | 49 | .001 | 0.22 | 206 | 98 | 46 |
| More than or equal to 70 IU | 28 | 40 | — | — | — | 84¶ | 7¶ |
| mod-Rai | |||||||
| I | 73 | 32 | .002 | 0.18 | 292 | 97 | 53 |
| II-III | 96 | 91 | — | — | — | 91 | 19¶ |
| FISH | |||||||
| Normal‖ | 30 | 45 | .18 | 0.11 | 156 | NT | 46 |
| Abnormal | 41 | 40 | — | — | — | NT | 15¶ |
| β2M | |||||||
| Less than 2.2 g/L | 84 | 51 | .10 | 0.11 | 232 | 97 | 45 |
| More than or equal to 2.2 g/L | 50 | 47 | — | — | — | 88¶ | 14¶ |
| Age | |||||||
| Less than 65 years | 94 | 65 | .49 | 0.04 | 302 | 86 | 28 |
| More than or equal to 65 years | 79 | 64 | — | — | — | 73¶ | 35 |
CLL cases with low (<30%) or high (>30%) CD49d expression were characterized for the distribution of several factors (CD38 and ZAP-70 expression, IGHV mutational status, modified Rai stage, sCD23 and β2M serum levels, normal and abnormal FISH, age), which in our series had prognostic relevance for OS and/or TTT.
IGHV indicates immunoglobulin heavy variable chain; ZAP-70, zeta-chain-associated protein 70 kDa; sCD23, soluble CD23; mod-Rai, modified Rai staging system; FISH, fluorescence in situ hybridization; β2M, β2-microglobulin; NT, not tested; and —, not applicable.
For each variable, the selected cutoff points or the compared categories are indicated.
χ2 tests were performed to evaluate the association between CD49d expression (below or above the established threshold set at 30% of positive CLL cells) and other prognostic factors.
Spearman ρ was calculated to show the degree of rank correlation.
Values refer to the number of cases analyzed for a given feature.
Normal FISH category included cases with normal karyotypes, that is, lacking 11q−, 13q−, 17p−, and chromosome +12; abnormal FISH included cases with 11q− (16 cases), 13q− (35 cases), 17p− (5 cases), and +12 (25 cases); 10-years untreated was computed by comparing cases with normal karyotypes with cases with 11q−, 17p−, and +12.
P < .05 (log-rank test).