Table 4 Overall change in liver iron... | American Society of Hematology

Table 4

Overall change in liver iron concentration and serum ferritin levels according to splenectomy status, irrespective of type of chelation therapy received*

	Mean iron intake, mg/kg per day		Mean change in LIC ± SD, mg Fe/g dw		Mean change in serum ferritin ± SD, μg/L
Not splenectomized	0.43 ± 0.11	(n = 395)	–2.2 ± 6.7	(n = 364)	–168.1 ± 1131.8	(n = 379)
Splenectomized	0.33 ± 0.09	(n = 191)	–3.7 ± 7.3	(n = 177)	–519.3 ± 1343.3	(n = 184)
P value†	< .0001		.0163		.0013

	Mean iron intake, mg/kg per day		Mean change in LIC ± SD, mg Fe/g dw		Mean change in serum ferritin ± SD, μg/L
Not splenectomized	0.43 ± 0.11	(n = 395)	–2.2 ± 6.7	(n = 364)	–168.1 ± 1131.8	(n = 379)
Splenectomized	0.33 ± 0.09	(n = 191)	–3.7 ± 7.3	(n = 177)	–519.3 ± 1343.3	(n = 184)
P value†	< .0001		.0163		.0013

In the non-splenectomized and splenectomized patients, mean doses of deferasirox (20.9 and 20.2 mg/kg/d, respectively) and DFO (44.2 and 43.8 mg/kg, respectively) were similar.

†

Splenectomized vs non-splenectomized patients.

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