Multivariate analysis of post-HDT survival
| Variable . | n/N (%) . | Survival from 1st transplantation . | |
|---|---|---|---|
| HR (95% CI) . | P . | ||
| 3 or more transplantations* | — | 4.43 (3.63-5.41) | <.001 |
| Platelets less than 100×109/L | 231/2147 (11) | 1.82 (1.50-2.19) | <.001 |
| MDS-CAs* | — | 1.82 (1.38-2.40) | <.001 |
| Any cytogenetic abnormality (MM-CAs) | 781/2147 (36) | 1.77 (1.56-2.02) | <.001 |
| Age older than 70 years at 1st transplantation | 195/2147 (9) | 1.48 (1.21-1.82) | <.001 |
| B2M concentration 3.0 mg/L or higher | 695/2147 (32) | 1.46 (1.27-1.69) | <.001 |
| CRP concentration 6.0 mg/L or higher | 819/2147 (38) | 1.35 (1.18-1.54) | <.001 |
| Albumin concentration less than 3.0 g/dL | 147/2147 (7) | 1.32 (1.07-1.63) | .010 |
| Hb level less than 10 g/dL | 663/2147 (31) | 1.20 (1.04-1.38) | .012 |
| IgA isotype | 462/2147 (22) | 1.19 (1.03-1.39) | .022 |
| TT protocol | 957/2147 (45) | 0.49 (0.41-0.58) | <.001 |
| Non-TT protocol | 735/2147 (34) | 0.80 (0.69-0.93) | .004 |
| Female | 809/2147 (38) | 0.84 (0.74-0.96) | .010 |
| Variable . | n/N (%) . | Survival from 1st transplantation . | |
|---|---|---|---|
| HR (95% CI) . | P . | ||
| 3 or more transplantations* | — | 4.43 (3.63-5.41) | <.001 |
| Platelets less than 100×109/L | 231/2147 (11) | 1.82 (1.50-2.19) | <.001 |
| MDS-CAs* | — | 1.82 (1.38-2.40) | <.001 |
| Any cytogenetic abnormality (MM-CAs) | 781/2147 (36) | 1.77 (1.56-2.02) | <.001 |
| Age older than 70 years at 1st transplantation | 195/2147 (9) | 1.48 (1.21-1.82) | <.001 |
| B2M concentration 3.0 mg/L or higher | 695/2147 (32) | 1.46 (1.27-1.69) | <.001 |
| CRP concentration 6.0 mg/L or higher | 819/2147 (38) | 1.35 (1.18-1.54) | <.001 |
| Albumin concentration less than 3.0 g/dL | 147/2147 (7) | 1.32 (1.07-1.63) | .010 |
| Hb level less than 10 g/dL | 663/2147 (31) | 1.20 (1.04-1.38) | .012 |
| IgA isotype | 462/2147 (22) | 1.19 (1.03-1.39) | .022 |
| TT protocol | 957/2147 (45) | 0.49 (0.41-0.58) | <.001 |
| Non-TT protocol | 735/2147 (34) | 0.80 (0.69-0.93) | .004 |
| Female | 809/2147 (38) | 0.84 (0.74-0.96) | .010 |
Results are shown as n/N (%), where n indicates number with factor and N indicates number with valid data for factor. P values are from Wald chi-square test in Cox regression. Other variables include white count, creatinine level (univariately significant), LDH level, and second transplantation (univariately significant; time dependent).
HR indicates hazard ratio; 95% CI, 95% confidence interval.
Time-dependent covariates.