Multivariate analyses for time to MDS-CAs
| Variable . | n/N (%) . | Time to MDS-CA . | |
|---|---|---|---|
| HR (95% CI) . | P . | ||
| All 105 patients* | |||
| Total CD34 collected less than 3×106/kg | 57/2313 (2) | 3.47 (1.77-6.77) | <.001 |
| Time interval from diagnosis to 1st transplantation more than 30 mo | 277/2313 (12) | 2.08 (1.27-3.40) | .004 |
| Age 70 y or older | 213/2313 (9) | 2.00 (1.08-3.70) | .027 |
| Platelet recovery 3 mo after 1st transplantation less than 150 × 109/L† | — | 1.79 (1.16-2.77) | .008 |
| 33 patients with persistent MDS-CA‡ | |||
| Total CD34 collected less than 3×106/kg | 81/2457 (3) | 3.34 (1.01-11.04) | .048 |
| CD34 harvest for more than 2 d | 95/2457 (4) | 3.36 (1.17-9.65) | .025 |
| Variable . | n/N (%) . | Time to MDS-CA . | |
|---|---|---|---|
| HR (95% CI) . | P . | ||
| All 105 patients* | |||
| Total CD34 collected less than 3×106/kg | 57/2313 (2) | 3.47 (1.77-6.77) | <.001 |
| Time interval from diagnosis to 1st transplantation more than 30 mo | 277/2313 (12) | 2.08 (1.27-3.40) | .004 |
| Age 70 y or older | 213/2313 (9) | 2.00 (1.08-3.70) | .027 |
| Platelet recovery 3 mo after 1st transplantation less than 150 × 109/L† | — | 1.79 (1.16-2.77) | .008 |
| 33 patients with persistent MDS-CA‡ | |||
| Total CD34 collected less than 3×106/kg | 81/2457 (3) | 3.34 (1.01-11.04) | .048 |
| CD34 harvest for more than 2 d | 95/2457 (4) | 3.36 (1.17-9.65) | .025 |
Multivariate model uses stepwise selection with entry level 0.1, and variable remains if it meets the 0.05 level. P values are from Wald chi-square test in Cox regression.
HR indicates hazard ratio; 95% CI, 95% confidence interval; and —, not applicable.
For these patients, other variables include time from first therapy to first transplantation (univariately significant), hemoglobin level, platelet count, LDH level, albumin concentration, B2M concentration, creatinine level, cytogenetic abnormalities, 3 or more transplantations (time dependent), and platelet recovery at approximately 3 months after second transplantation (time dependent).
Time-dependent variables.
For these patients, other variables include age, time from first therapy to first transplantation (univariately significant), hemoglobin level, platelet count, LDH level, albumin concentration, B2M concentration, creatinine level, cytogenetic abnormalities, 3 or more transplantations (time dependent), and platelet recovery at approximately 3 months after first and second transplantation (time dependent).