Table 4 Plasma pharmacokinetic... | American Society of Hematology

Table 4

Plasma pharmacokinetic parameters

Dose (mg/kg/d)/ patient ID no.	Age, y	Dose, mg/day	As^III AUC_0-24h, μM-h	Total Arsenic					Ratio of As^III to total AUC_0-24
Dose (mg/kg/d)/ patient ID no.	Age, y	Dose, mg/day	As^III AUC_0-24h, μM-h	AUC_0-24h, μM-h	C_maxμm	Before dose 2 μm	Before dose 5 μm	Before dose 20 μm	Ratio of As^III to total AUC_0-24
0.07, 18*	19	8.82	0.83	1.67	0.27	0.07	0.18	0.25	0.50
0.1, 20*0.15	19	10	0.70	2.00	0.23	0.06	0.10	0.27	0.35
1	17	14.8	2.06	3.23	0.22	0.10	0.26	0.39	0.64
2	13	5.8	1.90	3.00	0.21	0.11	ND	ND	0.63
4	14	10	1.80	2.89	0.26	0.11	<LLQ	<LLQ	0.62
5	9	3.8	1.84	3.44	0.37	0.12	0.21	ND	0.54
6	18	7.9	2.12	1.77	0.30	0.03	0.12	ND	1.22
10	17	7.9	2.75	3.85	0.26	0.17	0.35	ND	0.71
16	20	11	0.46	1.46	0.11	0.07	0.19	0.32	0.31
17	5	3.3	1.14	1.85	0.24	0.04	ND	ND	0.62
19	4	2.9	1.12	2.58	0.27	0.11	0.18	0.26	0.43
22	12	6	1.17	2.42	0.28	0.07	0.20	0.24	0.48
Median	13.5	7.0	1.82	2.74	0.26	0.11	0.20	0.26	0.62
Range	4-20	2.9-14.8	0.46-2.75	1.46-3.85	0.11-0.37	0.03-0.12	0-0.35	0-0.39	0.31-1.22
0.2
8	16	12	2.72	4.77	0.40	0.16	0.58	ND	0.57
9	3	3.08	2.77	4.37	0.46	0.12	0.25	0.35	0.63

Dose (mg/kg/d)/ patient ID no.	Age, y	Dose, mg/day	As^III AUC_0-24h, μM-h	Total Arsenic					Ratio of As^III to total AUC_0-24
Dose (mg/kg/d)/ patient ID no.	Age, y	Dose, mg/day	As^III AUC_0-24h, μM-h	AUC_0-24h, μM-h	C_maxμm	Before dose 2 μm	Before dose 5 μm	Before dose 20 μm	Ratio of As^III to total AUC_0-24
0.07, 18*	19	8.82	0.83	1.67	0.27	0.07	0.18	0.25	0.50
0.1, 20*0.15	19	10	0.70	2.00	0.23	0.06	0.10	0.27	0.35
1	17	14.8	2.06	3.23	0.22	0.10	0.26	0.39	0.64
2	13	5.8	1.90	3.00	0.21	0.11	ND	ND	0.63
4	14	10	1.80	2.89	0.26	0.11	<LLQ	<LLQ	0.62
5	9	3.8	1.84	3.44	0.37	0.12	0.21	ND	0.54
6	18	7.9	2.12	1.77	0.30	0.03	0.12	ND	1.22
10	17	7.9	2.75	3.85	0.26	0.17	0.35	ND	0.71
16	20	11	0.46	1.46	0.11	0.07	0.19	0.32	0.31
17	5	3.3	1.14	1.85	0.24	0.04	ND	ND	0.62
19	4	2.9	1.12	2.58	0.27	0.11	0.18	0.26	0.43
22	12	6	1.17	2.42	0.28	0.07	0.20	0.24	0.48
Median	13.5	7.0	1.82	2.74	0.26	0.11	0.20	0.26	0.62
Range	4-20	2.9-14.8	0.46-2.75	1.46-3.85	0.11-0.37	0.03-0.12	0-0.35	0-0.39	0.31-1.22
0.2
8	16	12	2.72	4.77	0.40	0.16	0.58	ND	0.57
9	3	3.08	2.77	4.37	0.46	0.12	0.25	0.35	0.63

These patients were treated at the 0.15 mg/kg/day dose level using ideal body weight to calculate the dose rather than the actual weight. Doses shown represent the dose per actual body weight.

ND indicates sample not drawn; and <LLQ, less than lower limit of quantification

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