Table 4 Prognostic relevance for overall... | American Society of Hematology

Table 4

Prognostic relevance for overall survival according to univariate Cox regression

Candidate prognostic factor	Comparison	n	RR	95% LCL	95% UCL	P
Age	10 years older	455	1.38	1.15	1.65	<.001
Sex	Male vs female	455	1.12	0.77	1.63	.55
ECOG performance status	1 vs 0	452	1.61	1.10	2.35	.014
ECOG performance status	2-4 vs 0	452	4.80	2.84	8.12	<.001
ECOG performance status	2-4 vs 0-1	452	3.48	2.22	5.43	<.001
Ann Arbor stage	IV vs III	455	1.09	0.70	1.70	.70
B-symptoms	present vs absent	451	1.60	1.17	2.19	.003
Bone marrow	involved vs not	453	1.04	0.70	1.54	.85
No. of extranodal sites	1 vs 0	445	1.25	0.72	2.16	.42
No. of extranodal sites	> 1 vs 0	445	1.57	0.89	2.77	.12
No. of extranodal sites	> 1 vs 0-1	445	1.30	0.94	1.80	.11
No. nodal areas	1 more	432	1.03	0.97	1.08	.34
Maximum tumor size	1 cm larger	387	1.06	1.01	1.10	.016
Spleen	involved vs not	420	1.40	1.01	1.95	.044
WBC count	10-fold*	451	2.25	1.59	3.18	<.001
Lymphocyte count	10-fold*	422	1.97	1.40	2.77	<.001
Granulocyte count	10-fold*	412	4.69	2.06	10.71	<.001
Monocyte count	10-fold*	408	2.61	1.65	4.12	<.001
Platelet count	100 ×10⁹/L more	452	1.01	0.88	1.16	.89
LDH	2-fold*	443	1.72	1.32	2.24	<.001
Hemoglobin	10 g/L more†	451	0.91	0.85	0.98	.009
Albumin	+ULN‡	268	0.23	0.05	1.08	.063
β₂-microglobulin	2-fold*	285	1.53	1.22	1.92	<.001

Candidate prognostic factor	Comparison	n	RR	95% LCL	95% UCL	P
Age	10 years older	455	1.38	1.15	1.65	<.001
Sex	Male vs female	455	1.12	0.77	1.63	.55
ECOG performance status	1 vs 0	452	1.61	1.10	2.35	.014
ECOG performance status	2-4 vs 0	452	4.80	2.84	8.12	<.001
ECOG performance status	2-4 vs 0-1	452	3.48	2.22	5.43	<.001
Ann Arbor stage	IV vs III	455	1.09	0.70	1.70	.70
B-symptoms	present vs absent	451	1.60	1.17	2.19	.003
Bone marrow	involved vs not	453	1.04	0.70	1.54	.85
No. of extranodal sites	1 vs 0	445	1.25	0.72	2.16	.42
No. of extranodal sites	> 1 vs 0	445	1.57	0.89	2.77	.12
No. of extranodal sites	> 1 vs 0-1	445	1.30	0.94	1.80	.11
No. nodal areas	1 more	432	1.03	0.97	1.08	.34
Maximum tumor size	1 cm larger	387	1.06	1.01	1.10	.016
Spleen	involved vs not	420	1.40	1.01	1.95	.044
WBC count	10-fold*	451	2.25	1.59	3.18	<.001
Lymphocyte count	10-fold*	422	1.97	1.40	2.77	<.001
Granulocyte count	10-fold*	412	4.69	2.06	10.71	<.001
Monocyte count	10-fold*	408	2.61	1.65	4.12	<.001
Platelet count	100 ×10⁹/L more	452	1.01	0.88	1.16	.89
LDH	2-fold*	443	1.72	1.32	2.24	<.001
Hemoglobin	10 g/L more†	451	0.91	0.85	0.98	.009
Albumin	+ULN‡	268	0.23	0.05	1.08	.063
β₂-microglobulin	2-fold*	285	1.53	1.22	1.92	<.001

LCL indicates lower confidence limit; UCL, upper confidence limit; and RR, relative risk.

Log scale

No significant interaction of hemoglobin and sex (P = .43)

Quotient to ULN