Multivariate analysis of overall survival in 86 T-PLL patients based on Cox proportional hazards model integrating molecular and clinical features
| Prognostic factor . | Risk of disease-related death . | ||
|---|---|---|---|
| Relative risk . | Standard error . | P . | |
| Model including tumor features and age | |||
| Age over 65 y | 1.9 | 0.26 | .015 |
| High TCL1 | 1.7 | 0.28 | .049 |
| pAKT-S473+ | 2.9 | 0.45 | .03 |
| sTCR+ | 2.2 | 0.37 | .02 |
| Model with inclusion of clinical parameters | |||
| Age over 65 y | 2.4 | 0.27 | .001 |
| WBC count over 40 ×109/L* | 2.2 | 0.28 | .006 |
| LDT, 3-tier* | 2.2 | 0.22 | <.001 |
| sTCR+ | 2.6 | 0.37 | .01 |
| Prognostic factor . | Risk of disease-related death . | ||
|---|---|---|---|
| Relative risk . | Standard error . | P . | |
| Model including tumor features and age | |||
| Age over 65 y | 1.9 | 0.26 | .015 |
| High TCL1 | 1.7 | 0.28 | .049 |
| pAKT-S473+ | 2.9 | 0.45 | .03 |
| sTCR+ | 2.2 | 0.37 | .02 |
| Model with inclusion of clinical parameters | |||
| Age over 65 y | 2.4 | 0.27 | .001 |
| WBC count over 40 ×109/L* | 2.2 | 0.28 | .006 |
| LDT, 3-tier* | 2.2 | 0.22 | <.001 |
| sTCR+ | 2.6 | 0.37 | .01 |
Both TCL1 and pAKT levels showed a strong positive correlation with each of these clinical parameters and were therefore not retained in this regression analysis.