Multivariate analyses of risk factors for NRM and survival among FHCRC and MDACC patients
| Risk factor . | NRM . | Survival . | ||||||
|---|---|---|---|---|---|---|---|---|
| FHCRC . | MDACC . | FHCRC . | MDACC . | |||||
| HR . | 95% CI . | HR . | 95% CI . | HR . | 95% CI . | HR . | 95% CI . | |
| HCT-CI risk | ||||||||
| Low | 1.0 | — | 1.0 | — | 1.0 | — | 1.0 | — |
| Intermediate | 3.43 | 1.3-9.2 | 4.93 | 0.4-55 | 3.31 | 1.6-6.9 | 2.60 | 0.7-9.6 |
| High | 8.12 | 3.0-22 | 5.05 | 0.6-43 | 7.45 | 3.6-15 | 2.32 | 0.8-7.1 |
| Cytogenetics | ||||||||
| Favorable/intermediate | 1.0 | — | 1.0 | — | 1.0 | — | 1.0 | — |
| Unfavorable | 1.61 | 0.6-4.2 | 1.19 | 0.4-3.9 | 1.44 | 0.7-3.1 | 1.07 | 0.5-2.3 |
| Donor | ||||||||
| Related | 1.0 | — | 1.0 | — | 1.0 | — | 1.0 | — |
| Unrelated | 2.16 | 0.9-5.0 | 0.44 | 0.1-3.7 | 1.91 | 1.0-3.6 | 1.61 | 0.6-4.4 |
| Stem-cell source | ||||||||
| G-PBMC | 1.0 | — | 1.0 | — | 1.0 | — | 1.0 | — |
| Marrow | 3.39 | 1.2-10 | 1.47 | 0.4-5.5 | 2.62 | 1.2-5.7 | 0.82 | 0.3-2.0 |
| Conditioning | ||||||||
| Ablative | 1.0 | — | 1.0 | — | 1.0 | — | 1.0 | — |
| Reduced-intensity | 0.00 | 0-Undefined | 2.51 | 0.6-11 | 3.85 | 0.7-20 | 1.62 | 0.6-4.3 |
| Nonablative | 0.81 | 0.1-4.5 | 0.87 | 0.1-11 | 0.87 | 0.3-3.0 | 0.57 | 0.1-3.3 |
| Age | ||||||||
| Younger than 50 y | 1.0 | — | 1.0 | — | 1.0 | — | 1.0 | — |
| 50 y or older | 1.64 | 0.7-3.8 | 0.83 | 0.2-3.6 | 1.74 | 0.9-3.3 | 0.93 | 0.3-2.7 |
| Risk factor . | NRM . | Survival . | ||||||
|---|---|---|---|---|---|---|---|---|
| FHCRC . | MDACC . | FHCRC . | MDACC . | |||||
| HR . | 95% CI . | HR . | 95% CI . | HR . | 95% CI . | HR . | 95% CI . | |
| HCT-CI risk | ||||||||
| Low | 1.0 | — | 1.0 | — | 1.0 | — | 1.0 | — |
| Intermediate | 3.43 | 1.3-9.2 | 4.93 | 0.4-55 | 3.31 | 1.6-6.9 | 2.60 | 0.7-9.6 |
| High | 8.12 | 3.0-22 | 5.05 | 0.6-43 | 7.45 | 3.6-15 | 2.32 | 0.8-7.1 |
| Cytogenetics | ||||||||
| Favorable/intermediate | 1.0 | — | 1.0 | — | 1.0 | — | 1.0 | — |
| Unfavorable | 1.61 | 0.6-4.2 | 1.19 | 0.4-3.9 | 1.44 | 0.7-3.1 | 1.07 | 0.5-2.3 |
| Donor | ||||||||
| Related | 1.0 | — | 1.0 | — | 1.0 | — | 1.0 | — |
| Unrelated | 2.16 | 0.9-5.0 | 0.44 | 0.1-3.7 | 1.91 | 1.0-3.6 | 1.61 | 0.6-4.4 |
| Stem-cell source | ||||||||
| G-PBMC | 1.0 | — | 1.0 | — | 1.0 | — | 1.0 | — |
| Marrow | 3.39 | 1.2-10 | 1.47 | 0.4-5.5 | 2.62 | 1.2-5.7 | 0.82 | 0.3-2.0 |
| Conditioning | ||||||||
| Ablative | 1.0 | — | 1.0 | — | 1.0 | — | 1.0 | — |
| Reduced-intensity | 0.00 | 0-Undefined | 2.51 | 0.6-11 | 3.85 | 0.7-20 | 1.62 | 0.6-4.3 |
| Nonablative | 0.81 | 0.1-4.5 | 0.87 | 0.1-11 | 0.87 | 0.3-3.0 | 0.57 | 0.1-3.3 |
| Age | ||||||||
| Younger than 50 y | 1.0 | — | 1.0 | — | 1.0 | — | 1.0 | — |
| 50 y or older | 1.64 | 0.7-3.8 | 0.83 | 0.2-3.6 | 1.74 | 0.9-3.3 | 0.93 | 0.3-2.7 |
— indicates not applicable.