Definitions and weighted scores of comorbidities as summarized by the hematopoietic cell transplantation–specific comorbidity index (HCT-CI)
| Comorbidities . | Definitions . | HCT-CI weighted scores . |
|---|---|---|
| Arrhythmia | Atrial fibrillation or flutter, sick sinus syndrome, or ventricular arrhythmias | 1 |
| Cardiac | Coronary artery disease,* congestive heart failure, myocardial infarction, or EF of ≤50% | 1 |
| Inflammatory bowel disease | Crohn's disease or ulcerative colitis | 1 |
| Diabetes | Requiring treatment with insulin or oral hypoglycemic, but not controlled with diet alone | 1 |
| Cerebrovascular disease | Transient ischemic attacks or cerebrovascular accident | 1 |
| Psychiatric disturbance | Depression/anxiety requiring psychiatric consult and/or treatment at the time of HCT | 1 |
| Hepatic, mild | Chronic hepatitis, bilirubin >ULN to 1.5× ULN, or AST/ALT >ULN to 2.5× ULN | 1 |
| Obesity | Patients with a BMI of >35 for adults or with BMI-for-age percentile of ≥ 95th percentile for children | 1 |
| Infection | Documented infection or fever of unknown etiology requiring antimicrobial treatment before, during, and after the start of conditioning regimen | 1 |
| Rheumatologic | SLE, RA, polymyositis, mixed CTD, and polymyalgia rheumatica | 2 |
| Peptic ulcer | Requiring treatment | 2 |
| Moderate/severe renal | Serum creatinine >2 mg/dL†, on dialysis, or prior to renal transplantation | 2 |
| Moderate pulmonary | DLco and/or FEV1 66%-80% or dyspnea on slight activity | 2 |
| Prior solid malignancy | Treated at any time point in the patient's history, excluding nonmelanoma skin cancer | 3 |
| Heart valve disease | Except asymptomatic mitral valve prolapse | 3 |
| Severe pulmonary | DLco and/or FEV1 ≤65% or dyspnea at rest or requiring oxygen | 3 |
| Moderate/severe hepatic | Liver cirrhosis, bilirubin >1.5× ULN, or AST/ALT >2.5× ULN | 3 |
| Comorbidities . | Definitions . | HCT-CI weighted scores . |
|---|---|---|
| Arrhythmia | Atrial fibrillation or flutter, sick sinus syndrome, or ventricular arrhythmias | 1 |
| Cardiac | Coronary artery disease,* congestive heart failure, myocardial infarction, or EF of ≤50% | 1 |
| Inflammatory bowel disease | Crohn's disease or ulcerative colitis | 1 |
| Diabetes | Requiring treatment with insulin or oral hypoglycemic, but not controlled with diet alone | 1 |
| Cerebrovascular disease | Transient ischemic attacks or cerebrovascular accident | 1 |
| Psychiatric disturbance | Depression/anxiety requiring psychiatric consult and/or treatment at the time of HCT | 1 |
| Hepatic, mild | Chronic hepatitis, bilirubin >ULN to 1.5× ULN, or AST/ALT >ULN to 2.5× ULN | 1 |
| Obesity | Patients with a BMI of >35 for adults or with BMI-for-age percentile of ≥ 95th percentile for children | 1 |
| Infection | Documented infection or fever of unknown etiology requiring antimicrobial treatment before, during, and after the start of conditioning regimen | 1 |
| Rheumatologic | SLE, RA, polymyositis, mixed CTD, and polymyalgia rheumatica | 2 |
| Peptic ulcer | Requiring treatment | 2 |
| Moderate/severe renal | Serum creatinine >2 mg/dL†, on dialysis, or prior to renal transplantation | 2 |
| Moderate pulmonary | DLco and/or FEV1 66%-80% or dyspnea on slight activity | 2 |
| Prior solid malignancy | Treated at any time point in the patient's history, excluding nonmelanoma skin cancer | 3 |
| Heart valve disease | Except asymptomatic mitral valve prolapse | 3 |
| Severe pulmonary | DLco and/or FEV1 ≤65% or dyspnea at rest or requiring oxygen | 3 |
| Moderate/severe hepatic | Liver cirrhosis, bilirubin >1.5× ULN, or AST/ALT >2.5× ULN | 3 |
Data are from Sorror et al.12
EF indicates ejection fraction; ULN, upper limit of normal; AST, aspartate aminotransferase; ALT, alanine aminotransferase; BMI, body mass index; SLE, systemic lupus erythematosus; RA, rheumatoid arthritis; CTD, connective tissue disease; DLco, diffusion capacity of carbon monoxide; and FEV1, forced expiratory volume in one second.
One or more vessel-coronary artery stenoses, requiring medical treatment, stent, or bypass graft.
To convert creatinine from milligrams per deciliter to micromoles per liter, multiply milligrams per deciliter by 88.4.