WAS-associated sequelae
| Donor group and age, y, at HSCT . | Score . | Splenectomy . | Type of sequelae . |
|---|---|---|---|
| MSD* | |||
| 0.8 | 5 | + | Severe hearing deficiency |
| 1.8 | 5 | + | Severe hearing deficiency |
| 1.3 | 4 | + | Chronic sinusitis/mastoiditis; severe growth retardation |
| 2.3 | 5 | + | Bilateral equinus, spasticity, learning difficulties |
| 7.0 | 5 | + | Bronchiectasis, chronic restrictive pulmonary disease |
| 2.5 | 5 | + | Scleroderma, Sjögren's syndrome |
| 8.5 | 5 | + | Extensive vitiligo |
| 10.8 | 5 | + | Bronchiectasis |
| URD† | |||
| 3.0 | 5 | + | Severe hearing deficiency |
| 5.5 | 5 | + | Anxiety, stereotype, school adaptation difficulties |
| 8.3 | 5 | + | Myocardial hypertrophy, retinopathy |
| 17.7 | 5 | + | Surgery for aortic root dilatation (vasculitis prior to HSCT) |
| 7.6 | 4 | − | Extensive chronic GVHD |
| 2.8 | 5 | − | Extensive chronic GVHD |
| MMRD‡ | |||
| 2.0 | 4 | + | Severe neurologic sequelae following pneumococcal meningitis |
| 1.8 | 4 | + | Tendon retractions requiring surgery |
| 2.4 | 4 | − | Severe neurologic sequelae following pneumococcal meningitis |
| 17.0 | 5 | + | Kidney transplant from mother |
| 4.5 | 5 | + | Epilepsy, cognitive deficiency |
| 5.0 | 5 | + | Severe anorexia due to chronic digestive GVHD |
| Donor group and age, y, at HSCT . | Score . | Splenectomy . | Type of sequelae . |
|---|---|---|---|
| MSD* | |||
| 0.8 | 5 | + | Severe hearing deficiency |
| 1.8 | 5 | + | Severe hearing deficiency |
| 1.3 | 4 | + | Chronic sinusitis/mastoiditis; severe growth retardation |
| 2.3 | 5 | + | Bilateral equinus, spasticity, learning difficulties |
| 7.0 | 5 | + | Bronchiectasis, chronic restrictive pulmonary disease |
| 2.5 | 5 | + | Scleroderma, Sjögren's syndrome |
| 8.5 | 5 | + | Extensive vitiligo |
| 10.8 | 5 | + | Bronchiectasis |
| URD† | |||
| 3.0 | 5 | + | Severe hearing deficiency |
| 5.5 | 5 | + | Anxiety, stereotype, school adaptation difficulties |
| 8.3 | 5 | + | Myocardial hypertrophy, retinopathy |
| 17.7 | 5 | + | Surgery for aortic root dilatation (vasculitis prior to HSCT) |
| 7.6 | 4 | − | Extensive chronic GVHD |
| 2.8 | 5 | − | Extensive chronic GVHD |
| MMRD‡ | |||
| 2.0 | 4 | + | Severe neurologic sequelae following pneumococcal meningitis |
| 1.8 | 4 | + | Tendon retractions requiring surgery |
| 2.4 | 4 | − | Severe neurologic sequelae following pneumococcal meningitis |
| 17.0 | 5 | + | Kidney transplant from mother |
| 4.5 | 5 | + | Epilepsy, cognitive deficiency |
| 5.0 | 5 | + | Severe anorexia due to chronic digestive GVHD |