Genes overexpressed in follicular lymphoma
| Gene name . | Gene description . | Genomic location . | Mean expression, log2 . |
|---|---|---|---|
| HIST1H4C | Histone 1, H4c | 6p22 | 2.722 |
| HIST1H4B | Histone 1, H4b | 6p22 | 2.346 |
| GCET1 (SERPINA9)* | Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 | 14q32 | 2.210 |
| SPIB | Spi-B transcription factor (Spi-1/PU.1 related) | 19q13 | 2.029 |
| HIST1H4H | Histone 1, H4h | 6p22 | 1.923 |
| TCL1A | T-cell leukemia/lymphoma 1A | 14q32 | 1.865 |
| HIST1H4J | Histone 1, H4j | 6p22 | 1.809 |
| VPREB3 | Pre-B lymphocyte gene 3 | 22q11 | 1.730 |
| DTX1* | Deltex homolog 1 (Drosophila) | 12q24 | 1.627 |
| KLHL14 | Kelch-like 14 (Drosophila) | 18q12 | 1.548 |
| MME* | Membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10*) | 3q25 | 1.498 |
| CD79B | CD79b molecule, immunoglobulin-associated beta | 17q23 | 1.338 |
| USP46 | Ubiquitin specific peptidase 46 | 4q11 | 1.326 |
| SYK | Spleen tyrosine kinase | 9q22 | 1.320 |
| CD80 | CD80 molecule | 3q13 | 1.307 |
| HLA-DQB1 | Major histocompatibility complex, class II, DQ beta 1 | 6p21 | 1.296 |
| CD79A | CD79a molecule, immunoglobulin-associated alpha | 19q13 | 1.280 |
| MGC2463 | Hypothetical protein LOC79037 | 7q22 | 1.192 |
| AICDA | Activation-induced cytidine deaminase | 12p13 | 1.185 |
| LOC90925 | Hypothetical protein LOC90925 | 14q32 | 1.156 |
| ENPP2 | Ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) | 8q24 | 1.152 |
| EOMES | Eomesodermin homolog (Xenopus laevis) | 3p24 | 1.149 |
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | 1q23 | 1.106 |
| BCL7A | B-cell CLL/lymphoma 7A | 12q24 | 1.069 |
| CCL4L | 17q12 | 1.056 | |
| SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | 22q11 | 1.052 |
| CD19 | CD19 molecule | 16p11 | 0.994 |
| KLHL6* | Kelch-like 6 (Drosophila) | 3q27 | 0.938 |
| ALOX5 | Arachidonate 5-lipoxygenase | 10q11 | 0.937 |
| BCAT1 | Branched chain aminotransferase 1, cytosolic | 12p12 | 0.918 |
| LRMP | Lymphoid-restricted membrane protein | 12p12 | 0.908 |
| Gene name . | Gene description . | Genomic location . | Mean expression, log2 . |
|---|---|---|---|
| HIST1H4C | Histone 1, H4c | 6p22 | 2.722 |
| HIST1H4B | Histone 1, H4b | 6p22 | 2.346 |
| GCET1 (SERPINA9)* | Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 | 14q32 | 2.210 |
| SPIB | Spi-B transcription factor (Spi-1/PU.1 related) | 19q13 | 2.029 |
| HIST1H4H | Histone 1, H4h | 6p22 | 1.923 |
| TCL1A | T-cell leukemia/lymphoma 1A | 14q32 | 1.865 |
| HIST1H4J | Histone 1, H4j | 6p22 | 1.809 |
| VPREB3 | Pre-B lymphocyte gene 3 | 22q11 | 1.730 |
| DTX1* | Deltex homolog 1 (Drosophila) | 12q24 | 1.627 |
| KLHL14 | Kelch-like 14 (Drosophila) | 18q12 | 1.548 |
| MME* | Membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10*) | 3q25 | 1.498 |
| CD79B | CD79b molecule, immunoglobulin-associated beta | 17q23 | 1.338 |
| USP46 | Ubiquitin specific peptidase 46 | 4q11 | 1.326 |
| SYK | Spleen tyrosine kinase | 9q22 | 1.320 |
| CD80 | CD80 molecule | 3q13 | 1.307 |
| HLA-DQB1 | Major histocompatibility complex, class II, DQ beta 1 | 6p21 | 1.296 |
| CD79A | CD79a molecule, immunoglobulin-associated alpha | 19q13 | 1.280 |
| MGC2463 | Hypothetical protein LOC79037 | 7q22 | 1.192 |
| AICDA | Activation-induced cytidine deaminase | 12p13 | 1.185 |
| LOC90925 | Hypothetical protein LOC90925 | 14q32 | 1.156 |
| ENPP2 | Ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) | 8q24 | 1.152 |
| EOMES | Eomesodermin homolog (Xenopus laevis) | 3p24 | 1.149 |
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | 1q23 | 1.106 |
| BCL7A | B-cell CLL/lymphoma 7A | 12q24 | 1.069 |
| CCL4L | 17q12 | 1.056 | |
| SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | 22q11 | 1.052 |
| CD19 | CD19 molecule | 16p11 | 0.994 |
| KLHL6* | Kelch-like 6 (Drosophila) | 3q27 | 0.938 |
| ALOX5 | Arachidonate 5-lipoxygenase | 10q11 | 0.937 |
| BCAT1 | Branched chain aminotransferase 1, cytosolic | 12p12 | 0.918 |
| LRMP | Lymphoid-restricted membrane protein | 12p12 | 0.908 |
Expression level is measured as the log2 mean expression of the series.
Note the stronger expression of GCET1 compared with other well-established GC markers, such as MME (CD10) and BCL6 (not shown in the table), and novel GC markers such as KLHL6 and DTX1 .