Table 1 Comparison of histone... | American Society of Hematology

Table 1

Comparison of histone modifications and transcription factor binding at the human and mouse α globin loci

	MCS-R1		MCS-R2		MCS-R3		Human hoHS-12	Mouse HS-12	MCS-R4		MCS-P9
	Human HS-48	Mouse HS-31	Human HS-40	Mouse HS-26	Human HS-33	Mouse HS-21	Human hoHS-12	Mouse HS-12	Human HS-10	Mouse HS-8	Human α globin promoter	Mouse α globin promoter
H4ac	++	++	++	++	++	+++	−*	++*	++	++	++	++
H3ac	+	+	+	+	+	+	−*	+*	+	+	++	++
H3K4me1	++	++	++	++	++	++	−*	++*	++	++	++	++
H3K4me2	+	+	+	+	+	+	−*	+*	+	+	++	++
H3K4me3	−	−	−	−	−	−	−	−	−	−	+++	+++
GATA1	+	+	+	+	+	+	−*	+*	+	+	−*	+*
SCL	+	+	+	+	+	+	−*	+*	+	+	−	−
NF-E2	+	+	+	+	−	−	−*	+*	−	−	−	−
Pol2	+	+	+	+	+	+	−*	+*	+	+	++++	++++

	MCS-R1		MCS-R2		MCS-R3		Human hoHS-12	Mouse HS-12	MCS-R4		MCS-P9
	Human HS-48	Mouse HS-31	Human HS-40	Mouse HS-26	Human HS-33	Mouse HS-21	Human hoHS-12	Mouse HS-12	Human HS-10	Mouse HS-8	Human α globin promoter	Mouse α globin promoter
H4ac	++	++	++	++	++	+++	−*	++*	++	++	++	++
H3ac	+	+	+	+	+	+	−*	+*	+	+	++	++
H3K4me1	++	++	++	++	++	++	−*	++*	++	++	++	++
H3K4me2	+	+	+	+	+	+	−*	+*	+	+	++	++
H3K4me3	−	−	−	−	−	−	−	−	−	−	+++	+++
GATA1	+	+	+	+	+	+	−*	+*	+	+	−*	+*
SCL	+	+	+	+	+	+	−*	+*	+	+	−	−
NF-E2	+	+	+	+	−	−	−*	+*	−	−	−	−
Pol2	+	+	+	+	+	+	−*	+*	+	+	++++	++++

The table summarizes ChIP results from this study and from Anguita et al⁴ at erythroid-specific DHSs and α globin gene promoters. The multispecies conserved elements are annotated (as previously described in Hughes et al²) as MCS-R1-4 (regulatory elements) and MCS-P9 (α globin promoter).

Differences are shown.

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