Clinical and immunologic characteristics of patients with APS analyzed in this study
| Patient no. . | Age/sex . | Thrombosis . | Loss of pregnancy . | IgG anti-β2GPI antibodies (U/mL)† . | HLA class II alleles: DRB1 . | Frequency of β2GPI-reactive T cells in circulation/104 T cells . | Recognition of p276–290 by peripheral blood T cells . |
|---|---|---|---|---|---|---|---|
| APS1 | 51/F | None | + | 16 | *1502/*0405 | 4.5 | NT |
| APS2 | 43/F | DVT, stroke | + | >120 | *0405/*1202 | 2.9 | NT |
| APS3 | 46/F | DVT, PE, retinal artery thrombosis | + | >120 | *1502/*0901 | 6.8 | + |
| APS4 | 47/F | Stroke | + | >120 | *1501/*0403 | 8.1 | + |
| APS9 | 46/F | DVT, PE, stroke, amaurosis fugax | NA | >120 | *0901 | 12.4 | + |
| Patient no. . | Age/sex . | Thrombosis . | Loss of pregnancy . | IgG anti-β2GPI antibodies (U/mL)† . | HLA class II alleles: DRB1 . | Frequency of β2GPI-reactive T cells in circulation/104 T cells . | Recognition of p276–290 by peripheral blood T cells . |
|---|---|---|---|---|---|---|---|
| APS1 | 51/F | None | + | 16 | *1502/*0405 | 4.5 | NT |
| APS2 | 43/F | DVT, stroke | + | >120 | *0405/*1202 | 2.9 | NT |
| APS3 | 46/F | DVT, PE, retinal artery thrombosis | + | >120 | *1502/*0901 | 6.8 | + |
| APS4 | 47/F | Stroke | + | >120 | *1501/*0403 | 8.1 | + |
| APS9 | 46/F | DVT, PE, stroke, amaurosis fugax | NA | >120 | *0901 | 12.4 | + |
All patients were lupus anticoagulant positive; all DRB4 alleles were *0103.
DVT indicates deep venous thrombosis of lower extremity; PE, pulmonary embolism; NA, not applicable; and NT, not tested.
Normal range less than 3.5 U/mL.