Inhibitors tested on primary AML and normal specimens
| Activity . | Compound . | Cytotoxic . | Rapid kinetics . | |
|---|---|---|---|---|
| AML . | Normal . | |||
| GSK-3β inhibitor | TDZD-8 (4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione) | Yes | No | Yes |
| GSK-3β inhibitor | BIO | No | No | No |
| GSK-3β inhibitor | (5-Methyl-1H-pyrazol-3-yl)-(2-phenylquinazolin-4-yl)amine | No | No | No |
| GSK-3β inhibitor | 2-Chloro-1-(4,5-dibromo-thiophen-2-yl)-ethanone | Yes | Yes | No |
| GSK-3β inhibitor | TWS119 | No | No | No |
| GSK-3β inhibitor | SB-216763 | No | No | No |
| GSK-3β inhibitor | AR-A014418 | No | No | No |
| GSK-3β inhibitor | 1-Azakenpaullone | No | No | No |
| GSK-3β inhibitor | 2,4-Dibenzyl-5-oxothiadiazolidine-3-thione | No | No | No |
| Thiazolidine ring | Anthrax Lethal Factor protease inhibitor | No | No | No |
| (thiazolidinedione ring) | 2,4-thiazolidinedione | No | No | No |
| (Thiazolidinedione ring) PPARα/γ agonist | DRF 2519 | No | No | No |
| (Thiazolidinedione ring) PPARα/γ agonist | Troglitazone | Yes | Yes | No |
| (Thiazolidinedione ring) Erk inhibitor | -(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl | No | No | No |
| (Thiazolidinedione ring) PI3-K inhibitor | 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione | No | No | No |
| Activity . | Compound . | Cytotoxic . | Rapid kinetics . | |
|---|---|---|---|---|
| AML . | Normal . | |||
| GSK-3β inhibitor | TDZD-8 (4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione) | Yes | No | Yes |
| GSK-3β inhibitor | BIO | No | No | No |
| GSK-3β inhibitor | (5-Methyl-1H-pyrazol-3-yl)-(2-phenylquinazolin-4-yl)amine | No | No | No |
| GSK-3β inhibitor | 2-Chloro-1-(4,5-dibromo-thiophen-2-yl)-ethanone | Yes | Yes | No |
| GSK-3β inhibitor | TWS119 | No | No | No |
| GSK-3β inhibitor | SB-216763 | No | No | No |
| GSK-3β inhibitor | AR-A014418 | No | No | No |
| GSK-3β inhibitor | 1-Azakenpaullone | No | No | No |
| GSK-3β inhibitor | 2,4-Dibenzyl-5-oxothiadiazolidine-3-thione | No | No | No |
| Thiazolidine ring | Anthrax Lethal Factor protease inhibitor | No | No | No |
| (thiazolidinedione ring) | 2,4-thiazolidinedione | No | No | No |
| (Thiazolidinedione ring) PPARα/γ agonist | DRF 2519 | No | No | No |
| (Thiazolidinedione ring) PPARα/γ agonist | Troglitazone | Yes | Yes | No |
| (Thiazolidinedione ring) Erk inhibitor | -(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl | No | No | No |
| (Thiazolidinedione ring) PI3-K inhibitor | 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione | No | No | No |