Table 1. Canadian Consensus Conference... | American Society of Hematology

Table 1.

Canadian Consensus Conference proposed criteria for transfusion-related acute lung injury (TRALI).

From Kleinman S, et al. Transfusion. 2004;44:1774–1789.

Criteria for TRALI

Acute lung injury (ALI)
- Acute onset
- Hypoxemia
  - In research setting:
    - Ratio of PaO₂/FiO₂ ≤ 300 or
    - SpO₂ < 90% on room air
  - Non-research setting:
    - Ratio of PaO₂/FiO₂ ≤ 300 or
    - SpO₂ < 90% on room air
    - Other clinical evidence of hypoxia
- Bilateral infiltrates on frontal chest radiograph
- No evidence of left atrial hypertension (i.e., circulatory overload)
No preexisting ALI before transfusion
During or within 6 hours of transfusion; and
No temporal relationship to an alternative risk factor for ALI

Criteria for possible TRALI

ALI
No preexisting ALI before transfusion
During or within 6 hours of transfusion; and
A clear temporal relationship to an alternative risk factor for ALI