ZAP-70 expression as detected by flow-cytometry and prognosis in chronic lymphocytic leukemia.
| Study . | N . | Survival (median) . | ZAP-70 < 20% (yrs) . | ZAP-70 ≥ 20% (yrs) . | P . |
|---|---|---|---|---|---|
| * Refers only to Binet A patients (N = 187) | |||||
| ** estimated | |||||
| Abbreviations: TTP, time to progression; OS, overall survival; TTT, time to treatment; TFS, treatment-free survival; PFS, progression-free survival | |||||
| Bosch et al23 | 222 | TTP* | Not reached | 3.3 | < 0.001 |
| OS | 16.3 | 8.5 | < 0.001 | ||
| Orchad et al20 | 167 | OS | 24.4 | 9.3 | < 0.001 |
| Rassenti et al21 | 307 | TTT | 9.2 | 2.9 | < 0.001 |
| Krober et al25 | 133 | TFS** | 7.16 | 2.5 | 0.005 |
| OS** | Not reached | 8.5 | 0.004 | ||
| Del Principe et al22 | 289 | PFS** | Not reached | 3.3 | < 0.001 |
| OS** | Not reached | 12 | < 0.001 | ||
| Study . | N . | Survival (median) . | ZAP-70 < 20% (yrs) . | ZAP-70 ≥ 20% (yrs) . | P . |
|---|---|---|---|---|---|
| * Refers only to Binet A patients (N = 187) | |||||
| ** estimated | |||||
| Abbreviations: TTP, time to progression; OS, overall survival; TTT, time to treatment; TFS, treatment-free survival; PFS, progression-free survival | |||||
| Bosch et al23 | 222 | TTP* | Not reached | 3.3 | < 0.001 |
| OS | 16.3 | 8.5 | < 0.001 | ||
| Orchad et al20 | 167 | OS | 24.4 | 9.3 | < 0.001 |
| Rassenti et al21 | 307 | TTT | 9.2 | 2.9 | < 0.001 |
| Krober et al25 | 133 | TFS** | 7.16 | 2.5 | 0.005 |
| OS** | Not reached | 8.5 | 0.004 | ||
| Del Principe et al22 | 289 | PFS** | Not reached | 3.3 | < 0.001 |
| OS** | Not reached | 12 | < 0.001 | ||