Table 1. Cytochrome P450 2C9 single... | American Society of Hematology

Table 1.

Cytochrome P450 2C9 single nucleotide polymorphisms (SNPs) that are known to affect warfarin metabolism.

	Prevalence (%)
Designation	Asian	White	Black	Protein Change	SNP	Effect on Warfarin Dose	Sample References
† CYP2C9*1 is the wild-type allele.
CYP2C9*1 †	98.2	80.3	94.2	none	none	referent
CYP2C9*2	0	12.7	3.4	Arg144Cys	C430T	−14% to −20%	26,39–42
CYP2C9*3	1.8	7.0	1.5	Ile359Leu	A1061C	−21% to −49%	26,39–42

	Prevalence (%)
Designation	Asian	White	Black	Protein Change	SNP	Effect on Warfarin Dose	Sample References
† CYP2C9*1 is the wild-type allele.
CYP2C9*1 †	98.2	80.3	94.2	none	none	referent
CYP2C9*2	0	12.7	3.4	Arg144Cys	C430T	−14% to −20%	26,39–42
CYP2C9*3	1.8	7.0	1.5	Ile359Leu	A1061C	−21% to −49%	26,39–42