Factor VIII (FVIII) immune tolerance induction (ITI) schedule.
| Initiate FVIII administration when inhibtor < 10 BUs (rFVIII 50 U/kg 3 times per week—200 U/kg/day) |
| ↓ |
| Follow FVIII inhibitor titer q weekly × 4 weeks then q 3 monthly |
| ↓ |
| When inhibitor disappears, maintain FVIII ITI until FVIII recovery > 66% predicted and FVIII half-life > 6 hours (check q 3 monthly) |
| ↓ |
| If ITI successful, start course of indefinite FVIII prophylaxis |
| ↓ |
| If inhibitor titer > 10 BUs after 12 months of ITI, initiate a salvage protocol |
| Initiate FVIII administration when inhibtor < 10 BUs (rFVIII 50 U/kg 3 times per week—200 U/kg/day) |
| ↓ |
| Follow FVIII inhibitor titer q weekly × 4 weeks then q 3 monthly |
| ↓ |
| When inhibitor disappears, maintain FVIII ITI until FVIII recovery > 66% predicted and FVIII half-life > 6 hours (check q 3 monthly) |
| ↓ |
| If ITI successful, start course of indefinite FVIII prophylaxis |
| ↓ |
| If inhibitor titer > 10 BUs after 12 months of ITI, initiate a salvage protocol |