Table 1.

Suggested thresholds defining failure, suboptimal response, and optimal response.

3 Months6 Months12 Months18 Months
Failure No hematologic response > 95% Ph+ > 35% Ph+ > 0% Ph+ 
Suboptimal Response No complete hematologic response 35–95% Ph+ 1–35% Ph+ 0% Ph+, < 3 log ⇓ in BCR-ABL transcripts 
Optimal response 1–2 log ⇓ in BCR-ABL transcripts < 35% Ph+ 0% Ph+, ≥ 3 log ⇓ in BCR-ABL transcripts 0% Ph+, ≥ 3 log ⇓ in BCR-ABL transcripts 
3 Months6 Months12 Months18 Months
Failure No hematologic response > 95% Ph+ > 35% Ph+ > 0% Ph+ 
Suboptimal Response No complete hematologic response 35–95% Ph+ 1–35% Ph+ 0% Ph+, < 3 log ⇓ in BCR-ABL transcripts 
Optimal response 1–2 log ⇓ in BCR-ABL transcripts < 35% Ph+ 0% Ph+, ≥ 3 log ⇓ in BCR-ABL transcripts 0% Ph+, ≥ 3 log ⇓ in BCR-ABL transcripts 
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