Selected clinical, laboratory, and outcome features of 148 adults and children with acute promyelocytic leukemia at 11 centers in Brazil.
| Hospital . | 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | 7 . | 8 . | 9 . | 10 . | 11 . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Abbreviations: AML, acute myeloid leukemia; WBC, white blood cell count; DIC, disseminated intravascular coagulation; CR, complete remission. Values are median (range) except where otherwise noted. | |||||||||||
| “Other failures” included infection (14 patients), abandonment/refusal of treatment (4), bleeding (8), ATRA syndrome (9), and myocardial infarction (1). In 10 patients more than one cause was noted. | |||||||||||
| No. patients | 12 | 10 | 6 | 5 | 13 | 5 | 9 | 12 | 16 | 39 | 21 |
| Age, years | 33 (11–57) | 29 (19–70) | 49 (33–72) | 13 (9–29) | 34 (18–79) | 44 (17–51) | 30 (17–48) | 42 (16–79) | 39 (17–65) | 28 (7–67) | 30 (5–78) |
| Sex (M/F ratio) | 0.7 | 0.6 | 1 | 0.6 | 1.1 | 0.25 | 1.1 | 1.2 | 1 | 0.9 | 0.4 |
| WBC × 109/L | 6.5 (0.9–402) | 4.9 (0.4–193) | 10.3 (1.5–38) | 5.5 (1.7–44.1) | 5.8 (0.7–110) | 5.5 (2–12.2) | 10 (0.3–64.2) | 6.3 (0.7–85.3) | 12.1 (1.1–403) | 4.4 (0.4–128) | 2.9 (0.7–147) |
| Platelet count × 109/L | NA | 20.5 (7–161) | 19 (10–41) | 19 (9–43) | 20 (5–67) | 49 (24–140) | 21 (10–41) | 23 (15–93) | 25.5 (9–48) | 24 (5–92) | 32 (10–193) |
| DIC (%) | 12 (100) | 0 | 6 (100) | 3 (60) | 6 (46) | 0 | 9 (82) | 7 (58) | 11 (69) | 10 (26) | 6 (29) |
| CR rate (%) | 6 (50) | 2 (20) | 4 (67) | 1 (20) | 10 (77) | 2 (40) | 2 (22.2) | 4 (33.3) | 7 (43.7) | 21 (54) | 14 (67) |
| Early death (%) | 4 (33.3) | 5 (50) | 1 (17) | 3 (60) | 2 (15) | 0 | 4 (44.5) | 2 (16.7) | 7 (43.7) | 9 (23) | 5 (24) |
| Relapse (%) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 (16.7) | 1 (6.2) | 1 (2.6) | 1 (4.8) |
| Other failures (%) | 1 (8.3) | 3 (30) | 1 (17) | 1 (20) | 2 (15) | 3 (60) | 2 (22.2) | 3 (25) | 2 (12.5) | 8 (21) | 2 (9.5) |
| Alive (%) | 7 (58.3) | 2 (20) | 4 (67) | 1 (20) | 9 (70) | 2 (40) | 3 (33.3) | 5 (41.6) | 6 (38) | 22 (56) | 14 (67) |
| Hospital . | 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | 7 . | 8 . | 9 . | 10 . | 11 . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Abbreviations: AML, acute myeloid leukemia; WBC, white blood cell count; DIC, disseminated intravascular coagulation; CR, complete remission. Values are median (range) except where otherwise noted. | |||||||||||
| “Other failures” included infection (14 patients), abandonment/refusal of treatment (4), bleeding (8), ATRA syndrome (9), and myocardial infarction (1). In 10 patients more than one cause was noted. | |||||||||||
| No. patients | 12 | 10 | 6 | 5 | 13 | 5 | 9 | 12 | 16 | 39 | 21 |
| Age, years | 33 (11–57) | 29 (19–70) | 49 (33–72) | 13 (9–29) | 34 (18–79) | 44 (17–51) | 30 (17–48) | 42 (16–79) | 39 (17–65) | 28 (7–67) | 30 (5–78) |
| Sex (M/F ratio) | 0.7 | 0.6 | 1 | 0.6 | 1.1 | 0.25 | 1.1 | 1.2 | 1 | 0.9 | 0.4 |
| WBC × 109/L | 6.5 (0.9–402) | 4.9 (0.4–193) | 10.3 (1.5–38) | 5.5 (1.7–44.1) | 5.8 (0.7–110) | 5.5 (2–12.2) | 10 (0.3–64.2) | 6.3 (0.7–85.3) | 12.1 (1.1–403) | 4.4 (0.4–128) | 2.9 (0.7–147) |
| Platelet count × 109/L | NA | 20.5 (7–161) | 19 (10–41) | 19 (9–43) | 20 (5–67) | 49 (24–140) | 21 (10–41) | 23 (15–93) | 25.5 (9–48) | 24 (5–92) | 32 (10–193) |
| DIC (%) | 12 (100) | 0 | 6 (100) | 3 (60) | 6 (46) | 0 | 9 (82) | 7 (58) | 11 (69) | 10 (26) | 6 (29) |
| CR rate (%) | 6 (50) | 2 (20) | 4 (67) | 1 (20) | 10 (77) | 2 (40) | 2 (22.2) | 4 (33.3) | 7 (43.7) | 21 (54) | 14 (67) |
| Early death (%) | 4 (33.3) | 5 (50) | 1 (17) | 3 (60) | 2 (15) | 0 | 4 (44.5) | 2 (16.7) | 7 (43.7) | 9 (23) | 5 (24) |
| Relapse (%) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 (16.7) | 1 (6.2) | 1 (2.6) | 1 (4.8) |
| Other failures (%) | 1 (8.3) | 3 (30) | 1 (17) | 1 (20) | 2 (15) | 3 (60) | 2 (22.2) | 3 (25) | 2 (12.5) | 8 (21) | 2 (9.5) |
| Alive (%) | 7 (58.3) | 2 (20) | 4 (67) | 1 (20) | 9 (70) | 2 (40) | 3 (33.3) | 5 (41.6) | 6 (38) | 22 (56) | 14 (67) |