Selected clinical, laboratory, and outcome features of 121 children with acute promyelocytic leukemia (APL).
| Features . | Culiacan, Mexico . | Guatemala City, Guatemala . | Managua, Nicaragua . | Recife, Brazil . | San Salvador, El Salvador . | San Jose, Costa Rica . | Tegucigalpa, Honduras . |
|---|---|---|---|---|---|---|---|
| Abbreviations: AML, acute myeloid leukemia; WBC, white blood cell count; DIC, disseminated intravascular coagulation; CR, complete remission. | |||||||
| Values shown are median (range). | |||||||
| Modified from Ribeiro RC and Razzouk B. (with permission). Haematologica Reports . 2005 ;1 :91 –93 | |||||||
| Period | 1989–2004 | 2000–2005 | 1995–2004 | 1997–2004 | 1998–2004 | 1996–2005 | 1998–2004 |
| Number of patients | 10 | 16 | 36 | 21 | 14 | 12 | 12 |
| Age, years (range) | 6.8 (11.1–16.0) | 8 (2.0–16.0) | 9 (2.7–16.4) | 11.4 (0.1–16.2) | 7.7 (0.8–17.7) | 7 (1.7–11.9) | 10.2 (2.6–16.1) |
| Sex (M/F ratio) | 2.3 | 1.0 | 1.0 | 1.6 | 2.5 | 0.5 | 1.4 |
| % of AML cases | 17.2 | 22.0 | 28.5 | 16.6 | 13.6 | 15.2 | 15.9 |
| WBC × 109/L | 45.6 (1.3–189.0) | 8.5 (1.1–143.0) | 10.0 (0.1–100.1) | 17.7 (1.1–121.3) | 11.9 (1.5–165.9) | 19.2 (0.8–124.0) | 17.7 (0.5–279.6) |
| Platelets × 109/L | 56.3 (22.0–100.0) | 30.0 (7.5–180.0) | 21.0 (1.3–54.0) | 18.0 (6.0–157.3) | 15.5 (1.3–143.4) | 32.5 (7.0–91.0) | 28.1 (4.0–160.0) |
| DIC (%) | 5 (50.0) | 7 (43.7) | 8 (22.2) | 4 (19.0) | 6 (42.8) | 4 (33.3) | 6 (50.0) |
| CR rate (%) | 6 (60.0) | 7 (43.7) | 20 (55.5) | 16 (76.1) | 7 (50.0) | 8 (66.6) | 5 (41.6) |
| Early death (%) | 1 (10.0) | 8 (50.0) | 6 (16.6) | 3 (14.2) | 4 (28.5) | 2 (16.6) | 4 (33.3) |
| Abandonment/refusal (%) | 2 (20.0) | 1 (6.2) | 4 (11.1) | 2 (9.5) | 1 (7.2) | 0 | 5 (41.6) |
| Relapse (%) | 2 (20.0) | 1 (6.2) | 14 (38.8) | 5 (23.8) | 2 (14.2) | 4 (33.3) | 0 |
| Other failures (%) | 1 (10.0) | 1 (6.25) | 6 (16.6) | 2 (9.5) | 1 (8.3) | 2 (16.6) | 2 (16.6) |
| Alive (%) | 4 (40.0) | 6 (37.5) | 6 (16.6) | 9 (42.8) | 6 (42.8) | 6 (50.0) | 1 (8.3) |
| Features . | Culiacan, Mexico . | Guatemala City, Guatemala . | Managua, Nicaragua . | Recife, Brazil . | San Salvador, El Salvador . | San Jose, Costa Rica . | Tegucigalpa, Honduras . |
|---|---|---|---|---|---|---|---|
| Abbreviations: AML, acute myeloid leukemia; WBC, white blood cell count; DIC, disseminated intravascular coagulation; CR, complete remission. | |||||||
| Values shown are median (range). | |||||||
| Modified from Ribeiro RC and Razzouk B. (with permission). Haematologica Reports . 2005 ;1 :91 –93 | |||||||
| Period | 1989–2004 | 2000–2005 | 1995–2004 | 1997–2004 | 1998–2004 | 1996–2005 | 1998–2004 |
| Number of patients | 10 | 16 | 36 | 21 | 14 | 12 | 12 |
| Age, years (range) | 6.8 (11.1–16.0) | 8 (2.0–16.0) | 9 (2.7–16.4) | 11.4 (0.1–16.2) | 7.7 (0.8–17.7) | 7 (1.7–11.9) | 10.2 (2.6–16.1) |
| Sex (M/F ratio) | 2.3 | 1.0 | 1.0 | 1.6 | 2.5 | 0.5 | 1.4 |
| % of AML cases | 17.2 | 22.0 | 28.5 | 16.6 | 13.6 | 15.2 | 15.9 |
| WBC × 109/L | 45.6 (1.3–189.0) | 8.5 (1.1–143.0) | 10.0 (0.1–100.1) | 17.7 (1.1–121.3) | 11.9 (1.5–165.9) | 19.2 (0.8–124.0) | 17.7 (0.5–279.6) |
| Platelets × 109/L | 56.3 (22.0–100.0) | 30.0 (7.5–180.0) | 21.0 (1.3–54.0) | 18.0 (6.0–157.3) | 15.5 (1.3–143.4) | 32.5 (7.0–91.0) | 28.1 (4.0–160.0) |
| DIC (%) | 5 (50.0) | 7 (43.7) | 8 (22.2) | 4 (19.0) | 6 (42.8) | 4 (33.3) | 6 (50.0) |
| CR rate (%) | 6 (60.0) | 7 (43.7) | 20 (55.5) | 16 (76.1) | 7 (50.0) | 8 (66.6) | 5 (41.6) |
| Early death (%) | 1 (10.0) | 8 (50.0) | 6 (16.6) | 3 (14.2) | 4 (28.5) | 2 (16.6) | 4 (33.3) |
| Abandonment/refusal (%) | 2 (20.0) | 1 (6.2) | 4 (11.1) | 2 (9.5) | 1 (7.2) | 0 | 5 (41.6) |
| Relapse (%) | 2 (20.0) | 1 (6.2) | 14 (38.8) | 5 (23.8) | 2 (14.2) | 4 (33.3) | 0 |
| Other failures (%) | 1 (10.0) | 1 (6.25) | 6 (16.6) | 2 (9.5) | 1 (8.3) | 2 (16.6) | 2 (16.6) |
| Alive (%) | 4 (40.0) | 6 (37.5) | 6 (16.6) | 9 (42.8) | 6 (42.8) | 6 (50.0) | 1 (8.3) |