Table 1. Comparison of genome-wide and... | American Society of Hematology

Table 1.

Comparison of genome-wide and candidate gene approaches to pharmacogenetic studies.

Candidate Gene Studies	Genome-Wide Studies
Rational selection of genes for study increases biological plausibility of findings, however novel genes cannot be identified.	Analysis of whole genome allows identification of genes not previously known to be important in response to drug.
Limited number of genes reduces possibility of false discovery.	Large number of analyses means significant risk of false discovery.
Expense reduced if candidate genes selected prove to be relevant to outcome.	Increased expense following up on large number of positive findings.
Moderate sample size may be adequate.	Large sample sizes are needed because of the large number of comparisons made.

Candidate Gene Studies	Genome-Wide Studies
Rational selection of genes for study increases biological plausibility of findings, however novel genes cannot be identified.	Analysis of whole genome allows identification of genes not previously known to be important in response to drug.
Limited number of genes reduces possibility of false discovery.	Large number of analyses means significant risk of false discovery.
Expense reduced if candidate genes selected prove to be relevant to outcome.	Increased expense following up on large number of positive findings.
Moderate sample size may be adequate.	Large sample sizes are needed because of the large number of comparisons made.