Ann Arbor staging system for Hodgkin lymphoma, including the Cotswolds modifications.
| Stage . | Disease Involvement . |
|---|---|
| I | Single lymph node region (I) or one extralymphatic site(IE) |
| II | Two or more lymph node regions, on the same side of the diaphragm (II) or local extralymphatic extension plus one or more lymph node regions on the same (IIE) |
| III | Lymph node regions on both sides of the diaphragm (III), which may be accompanied by local extralymphatic extension(IIIE) |
| IV | Diffuse involvement of one or more extralymphatic organs or sites |
| A | No B symptoms |
| B | Presence of at least one of: unexplained weight loss >10% baseline during 6 months prior to staging; recurrent unexplained fever > 38°C; recurrent night sweats |
| X | Bulky tumor: either a single mass exceeding 10 cm in largest diameter or a mediastinal mass exceeding one third of the maximum transverse transthoracic diameter measured on a standard posterior-anterior chest radiograph |
| Stage . | Disease Involvement . |
|---|---|
| I | Single lymph node region (I) or one extralymphatic site(IE) |
| II | Two or more lymph node regions, on the same side of the diaphragm (II) or local extralymphatic extension plus one or more lymph node regions on the same (IIE) |
| III | Lymph node regions on both sides of the diaphragm (III), which may be accompanied by local extralymphatic extension(IIIE) |
| IV | Diffuse involvement of one or more extralymphatic organs or sites |
| A | No B symptoms |
| B | Presence of at least one of: unexplained weight loss >10% baseline during 6 months prior to staging; recurrent unexplained fever > 38°C; recurrent night sweats |
| X | Bulky tumor: either a single mass exceeding 10 cm in largest diameter or a mediastinal mass exceeding one third of the maximum transverse transthoracic diameter measured on a standard posterior-anterior chest radiograph |