Molecular prognostic markers in follicular lymphoma.
| Prognostic Marker . | Effect on Outcome . | Mechanism . |
|---|---|---|
| *Table modified from Gascoyne41 (refer for full list of references), additional reference Torlakovic46 | ||
| Chromosomal gains +7, +12q13-14, +18q | Unfavorable | Dominant oncogenes |
| Chromosomal losses Del6q, −9p21, −17p13 | Unfavorable | Loss tumor suppressor gene |
| BCL-6 translocation | Unfavorable | Genomic instability |
| Bcl-2 expression | Unfavorable | Anti-apoptotic |
| Bcl-6 expression | Favorable | Germinal center phenotype |
| CD10 expression | Favorable | Germinal center phenotype |
| PU.1 | Favorable | Germinal center phenotype |
| Macrophage content | Unfavorable | Modulation by microenvironment |
| MDM2 expression | Unfavorable | Functional p53 loss |
| Bcl-XL | Unfavorable | Anti-apoptotic |
| Cyclin B1 | Favorable | Cell cycle progression |
| Immune response (IR-1 versus IR-2) | Variable | Modulation by microenvironment |
| 81-gene predictor | Variable | Reflects tumor behavior |
| Prognostic Marker . | Effect on Outcome . | Mechanism . |
|---|---|---|
| *Table modified from Gascoyne41 (refer for full list of references), additional reference Torlakovic46 | ||
| Chromosomal gains +7, +12q13-14, +18q | Unfavorable | Dominant oncogenes |
| Chromosomal losses Del6q, −9p21, −17p13 | Unfavorable | Loss tumor suppressor gene |
| BCL-6 translocation | Unfavorable | Genomic instability |
| Bcl-2 expression | Unfavorable | Anti-apoptotic |
| Bcl-6 expression | Favorable | Germinal center phenotype |
| CD10 expression | Favorable | Germinal center phenotype |
| PU.1 | Favorable | Germinal center phenotype |
| Macrophage content | Unfavorable | Modulation by microenvironment |
| MDM2 expression | Unfavorable | Functional p53 loss |
| Bcl-XL | Unfavorable | Anti-apoptotic |
| Cyclin B1 | Favorable | Cell cycle progression |
| Immune response (IR-1 versus IR-2) | Variable | Modulation by microenvironment |
| 81-gene predictor | Variable | Reflects tumor behavior |