Differential diagnosis of neutropenia.
| Acquired . |
|---|
| Table adapted from: Newburger PE. Neutropenia. In: Rakel RE, Bope ET, eds. Conn’s Current Therapy 2006. Philadelphia: Saunders Elsevier; 2006:502–505 |
| Bone marrow aplasia, dysplasia, or replacement |
| Drug-induced |
| impaired production (chemotherapy, phenothiazines, other drugs) |
| antibody-mediated (aminopyrine, other drugs) |
| Hypersplenism |
| Immune-mediated (alloimmune and autoimmune) |
| Nutritional (folate, vitamin B12) |
| Sepsis with exhaustion of bone marrow storage pool |
| Viral bone marrow suppression |
| Congenital |
| Cyclic hematopoiesis |
| Familial benign neutropenia |
| Myelokathexis |
| Severe chronic neutropenia |
| Complex syndromes including neutropenia |
| Cartilage-hair hypoplasia |
| Chédiak-Higashi syndrome |
| Dyskeratosis congenital |
| Primary immunodeficiencies (e.g., X-linked hyper-IgM syndrome) |
| Metabolic disorders (e.g., glycogen storage disease type 1b, organic acidurias) |
| Fanconi anemia |
| Reticular dysgenesis |
| Shwachman-Diamond syndrome |
| Acquired . |
|---|
| Table adapted from: Newburger PE. Neutropenia. In: Rakel RE, Bope ET, eds. Conn’s Current Therapy 2006. Philadelphia: Saunders Elsevier; 2006:502–505 |
| Bone marrow aplasia, dysplasia, or replacement |
| Drug-induced |
| impaired production (chemotherapy, phenothiazines, other drugs) |
| antibody-mediated (aminopyrine, other drugs) |
| Hypersplenism |
| Immune-mediated (alloimmune and autoimmune) |
| Nutritional (folate, vitamin B12) |
| Sepsis with exhaustion of bone marrow storage pool |
| Viral bone marrow suppression |
| Congenital |
| Cyclic hematopoiesis |
| Familial benign neutropenia |
| Myelokathexis |
| Severe chronic neutropenia |
| Complex syndromes including neutropenia |
| Cartilage-hair hypoplasia |
| Chédiak-Higashi syndrome |
| Dyskeratosis congenital |
| Primary immunodeficiencies (e.g., X-linked hyper-IgM syndrome) |
| Metabolic disorders (e.g., glycogen storage disease type 1b, organic acidurias) |
| Fanconi anemia |
| Reticular dysgenesis |
| Shwachman-Diamond syndrome |