Myeloma-related organ or tissue impairment.
| Criterion . | Diagnostic Parameters . |
|---|---|
| Hypercalcemia | Serum calcium > 0.25 mmol/L above the upper limit of normal, or > 2.75 mmol/L (> 11.0 mg/dL) |
| Renal insufficiency | Creatinine >173 mmol/L (> 1.9 mg/dL) |
| Anemia | Hemoglobin 2 g/dL below the lower limit of normal, or hemoglobin <10 g/dL |
| Bony lesions | Lytic bony lesions, or osteoporosis with compression fractures (possibly requiring magnetic resonance or computed tomography as part of the evaluation) |
| Other associated findings | Symptomatic hyperviscosity, amyloidosis, recurring bacterial infections (> 2 episodes in 12 months) |
| Criterion . | Diagnostic Parameters . |
|---|---|
| Hypercalcemia | Serum calcium > 0.25 mmol/L above the upper limit of normal, or > 2.75 mmol/L (> 11.0 mg/dL) |
| Renal insufficiency | Creatinine >173 mmol/L (> 1.9 mg/dL) |
| Anemia | Hemoglobin 2 g/dL below the lower limit of normal, or hemoglobin <10 g/dL |
| Bony lesions | Lytic bony lesions, or osteoporosis with compression fractures (possibly requiring magnetic resonance or computed tomography as part of the evaluation) |
| Other associated findings | Symptomatic hyperviscosity, amyloidosis, recurring bacterial infections (> 2 episodes in 12 months) |