World Health Organization (WHO) criteria for polycythemia vera (PV). Diagnosis of PV requires the presence of the first two A criteria together with either any one other A criterion or two B criteria.
A Criteria
Elevated red cell mass > 25% above mean normal predicted value, or hemoglobin > 18.5 g/dL in men, 16.5 g/dL in women, or > 99th percentile of method-specific reference range for age, sex, altitude of residence.
No cause of secondary erythrocytosis, including:
Absence of familial erythrocytosis
No elevation of erythropoietin due to;
= 92%) Hypoxia (arterial PO2
High oxygen affinity hemoglobin
Truncated erythropoietin receptor
Inappropriate erythropoietin production by tumor
Splenomegaly
Clonal genetic abnormality other than Philadelphia chromosome or BCR-ABL fusion gene in marrow cells
Endogenous erythroid colony formation in vitro
B Criteria
Thrombocytosis > 400 × 109/L
Leukocytosis > 12 × 109/L
Bone marrow biopsy showing panmyelosis with prominent erythroid and megakaryocytic proliferation4. Low serum erythropoietin levels
A Criteria
Elevated red cell mass > 25% above mean normal predicted value, or hemoglobin > 18.5 g/dL in men, 16.5 g/dL in women, or > 99th percentile of method-specific reference range for age, sex, altitude of residence.
No cause of secondary erythrocytosis, including:
Absence of familial erythrocytosis
No elevation of erythropoietin due to;
= 92%) Hypoxia (arterial PO2
High oxygen affinity hemoglobin
Truncated erythropoietin receptor
Inappropriate erythropoietin production by tumor
Splenomegaly
Clonal genetic abnormality other than Philadelphia chromosome or BCR-ABL fusion gene in marrow cells
Endogenous erythroid colony formation in vitro
B Criteria
Thrombocytosis > 400 × 109/L
Leukocytosis > 12 × 109/L
Bone marrow biopsy showing panmyelosis with prominent erythroid and megakaryocytic proliferation4. Low serum erythropoietin levels