Comparison of acute immune thrombocytopenic purpura (ITP) treatment regimens in children.
| Treatment Response . | Prednisone (4 mg/k/day 1–7, max 60 mg) . | IV Immunoglobulin (1–2 g/kg) . | Anti-D Immunoglobulin (75 μg/kg) . |
|---|---|---|---|
| Response > 20,000 at 48 hours | 60–70% of patients | 70–80% of patients | 77% of patients |
| Common side effects | Weight gain, irritability, hypertension, stomach pain, hyperglycemia | Post-infusion headache, vomiting, allergic reactions, fever, chills | Hemolysis, chills, fever, headache |
| Rare but severe reactions | Gastic ulcer, reflux, bleeding, hypertension-induced ICH | Anaphylaxis, aseptic meningitis, renal failure | Massive hemolysis with associated back pain myalgia, anemia |
| Duration of intial response (days) | Wide range of response after 30 days of weaning from initial dose to 0 | 21–72 days with platelet count greater than 20,000/mm3 | 21–48 days based on the75 μg/kg dose |
| Treatment Response . | Prednisone (4 mg/k/day 1–7, max 60 mg) . | IV Immunoglobulin (1–2 g/kg) . | Anti-D Immunoglobulin (75 μg/kg) . |
|---|---|---|---|
| Response > 20,000 at 48 hours | 60–70% of patients | 70–80% of patients | 77% of patients |
| Common side effects | Weight gain, irritability, hypertension, stomach pain, hyperglycemia | Post-infusion headache, vomiting, allergic reactions, fever, chills | Hemolysis, chills, fever, headache |
| Rare but severe reactions | Gastic ulcer, reflux, bleeding, hypertension-induced ICH | Anaphylaxis, aseptic meningitis, renal failure | Massive hemolysis with associated back pain myalgia, anemia |
| Duration of intial response (days) | Wide range of response after 30 days of weaning from initial dose to 0 | 21–72 days with platelet count greater than 20,000/mm3 | 21–48 days based on the75 μg/kg dose |