History and physical findings not consistent with immune thrombocytopenic purpura (ITP) of childhood.
| History/Findings . | Alternative Diagnosis . |
|---|---|
| Thrombocytopenia present from birth | Amegakaryocytosis Primary thrombocytopenia Giant platelet syndromes |
| Weight loss and recurrent fevers | Malignancy, immune deficiencies |
| Bloody diarrhea | Wiskott Aldrich Hemolytic uremic syndrome |
| Recurrent infections or failure to thrive | Primary immune disorder, HIV |
| History or presence of jaundice | Autoimmune hemolytic disease Hepatitis, cirrhosis with splenomegaly |
| Splenomegaly, lymphadenopathy | Autoimmune lymphoproliferative syndrome (ALPS), primary immune disorders, Gauchers malignancies, hypersplenism syndromes |
| Forearm or hand anomalies | Thrombocytopenia absent radii (TAR) Fanconi’s syndrome |
| Malar rash, dermatomyocytis, polymyocytis, eczema | Collagen vascular disease, Wiskott Aldrich |
| Cardiac malformation with or without DiGeorge syndrome | Chromosome 22 microdeletions with large platelets, with or without Evans syndrome |
| History/Findings . | Alternative Diagnosis . |
|---|---|
| Thrombocytopenia present from birth | Amegakaryocytosis Primary thrombocytopenia Giant platelet syndromes |
| Weight loss and recurrent fevers | Malignancy, immune deficiencies |
| Bloody diarrhea | Wiskott Aldrich Hemolytic uremic syndrome |
| Recurrent infections or failure to thrive | Primary immune disorder, HIV |
| History or presence of jaundice | Autoimmune hemolytic disease Hepatitis, cirrhosis with splenomegaly |
| Splenomegaly, lymphadenopathy | Autoimmune lymphoproliferative syndrome (ALPS), primary immune disorders, Gauchers malignancies, hypersplenism syndromes |
| Forearm or hand anomalies | Thrombocytopenia absent radii (TAR) Fanconi’s syndrome |
| Malar rash, dermatomyocytis, polymyocytis, eczema | Collagen vascular disease, Wiskott Aldrich |
| Cardiac malformation with or without DiGeorge syndrome | Chromosome 22 microdeletions with large platelets, with or without Evans syndrome |