Treatment outcome according to CNS1 status and traumatic lumbar puncture with blasts (TLP).
| Study . | CNS1 . | TLP . | Pvalue . |
|---|---|---|---|
| Abbreviations: BFM, Berlin-Frankfurt-Münster; CNS, central nervous system; EFS, event-free survival; SE, standard error; DCLSG, Dutch Childhood Leukemia Study Group; ALL, acute lymphoblastic lymphoma; SJCRH, St. Jude Children’s Research Hospital | |||
| BFM 95 (1995–1999)10 | |||
| No. patients | 1605 | 135 | |
| % CNS relapse at 5 yr | 3.5 | 8 | < 0.05 |
| % 5-yr EFS (SE) | 80 (1) | 73 (4) | 0.003 |
| DCLSG ALL 7 & 8 (1988–1997)14 | |||
| No. patients | 304 | 62 | |
| % CNS relapse at 10 yr | 4.9 | 8 | 0.24 |
| % 10-yr EFS (SE) | 72.6 (2.5) | 58 (7.6) | < 0.01 |
| SJCRH XI & XII (1984–1991)17 | |||
| No. patients | 336 | 60 | |
| % CNS relapse at 5 yr | 4.3 (1.1) | 7.3 (3.5) | 0.13 |
| % 5-yr EFS (SE) | 77 (2) | 60 (6) | 0.026 |
| SJCRH XIIIB (1994–1998)15 | |||
| No. patients | 145 | 17 | |
| % CNS relapse at 5 yr | 0.7 (0.7) | 0 | 0.73 |
| % 5-yr EFS (SE) | 80.6 (3.3) | 82.4 (8.9) | 0.67 |
| Study . | CNS1 . | TLP . | Pvalue . |
|---|---|---|---|
| Abbreviations: BFM, Berlin-Frankfurt-Münster; CNS, central nervous system; EFS, event-free survival; SE, standard error; DCLSG, Dutch Childhood Leukemia Study Group; ALL, acute lymphoblastic lymphoma; SJCRH, St. Jude Children’s Research Hospital | |||
| BFM 95 (1995–1999)10 | |||
| No. patients | 1605 | 135 | |
| % CNS relapse at 5 yr | 3.5 | 8 | < 0.05 |
| % 5-yr EFS (SE) | 80 (1) | 73 (4) | 0.003 |
| DCLSG ALL 7 & 8 (1988–1997)14 | |||
| No. patients | 304 | 62 | |
| % CNS relapse at 10 yr | 4.9 | 8 | 0.24 |
| % 10-yr EFS (SE) | 72.6 (2.5) | 58 (7.6) | < 0.01 |
| SJCRH XI & XII (1984–1991)17 | |||
| No. patients | 336 | 60 | |
| % CNS relapse at 5 yr | 4.3 (1.1) | 7.3 (3.5) | 0.13 |
| % 5-yr EFS (SE) | 77 (2) | 60 (6) | 0.026 |
| SJCRH XIIIB (1994–1998)15 | |||
| No. patients | 145 | 17 | |
| % CNS relapse at 5 yr | 0.7 (0.7) | 0 | 0.73 |
| % 5-yr EFS (SE) | 80.6 (3.3) | 82.4 (8.9) | 0.67 |