Table 1. Cumulative risk of isolated... | American Society of Hematology

Table 1.

Cumulative risk of isolated central nervous system (CNS) relapse according to CNS1 or 2 status in selected clinical trials.

			%Cumulative Risk
Study (Reference)	Study Period	Patient Group	CNS1	CNS2	Pvalue
Abbreviations: SJCRH, St. Jude Children’s Research Hospital; POG, Pediatric Oncology Group; BFM, Berlin-Frankfurt-Münster; CCG, Children’s Cancer Group; EORTC, European Organisation for Research and Treatment of Cancer; DCLSG, Dutch Childhood Leukemia Study Group; NS, not significant
SJCRH XI ⁸	1984–1988	All	4.0	13.0	< 0.001
POG 8602 ⁹	1986–1990	B-lineage	5.3	11.6	0.002
BFM 95 ¹⁰	1995–1999	All	3.5	10	< 0.05
CCG 1800/1900 ¹¹	1988–1993	All	3.9	7.7	0.0018
EORTC 58881 ¹²	1989–1998	All	8.1	15.7	—
CCG 105 13	1983–1989	Non-irradiated	6.5	11.8	0.15
CCG 105 ¹³	1983–1989	Irradiated	6.4	2.3	0.32
DCLSG ALL-7 & 8 ¹⁴	1988–1997	All	3.6	5.4	NS
SJCRH XIIIB ¹⁵	1994–1998	All	0.7	3.9	0.09

			%Cumulative Risk
Study (Reference)	Study Period	Patient Group	CNS1	CNS2	Pvalue
Abbreviations: SJCRH, St. Jude Children’s Research Hospital; POG, Pediatric Oncology Group; BFM, Berlin-Frankfurt-Münster; CCG, Children’s Cancer Group; EORTC, European Organisation for Research and Treatment of Cancer; DCLSG, Dutch Childhood Leukemia Study Group; NS, not significant
SJCRH XI ⁸	1984–1988	All	4.0	13.0	< 0.001
POG 8602 ⁹	1986–1990	B-lineage	5.3	11.6	0.002
BFM 95 ¹⁰	1995–1999	All	3.5	10	< 0.05
CCG 1800/1900 ¹¹	1988–1993	All	3.9	7.7	0.0018
EORTC 58881 ¹²	1989–1998	All	8.1	15.7	—
CCG 105 13	1983–1989	Non-irradiated	6.5	11.8	0.15
CCG 105 ¹³	1983–1989	Irradiated	6.4	2.3	0.32
DCLSG ALL-7 & 8 ¹⁴	1988–1997	All	3.6	5.4	NS
SJCRH XIIIB ¹⁵	1994–1998	All	0.7	3.9	0.09