TG and thrombin dynamics parameters in APS patients with and without prior thrombosis and without anticoagulant therapy
| Parameter . | No thrombosis . | Thrombosis . | P . |
|---|---|---|---|
| TG 1 pM TF | |||
| Lag time, min | 4.0 (4.0) | 4.0 (2.3) | NS |
| Time to peak, min | 8.0 (4.0) | 8.0 (2.3) | NS |
| Peak, nM | 238 (133) | 284 (93) | NS |
| ETP, nM × min | 1131 (212) | 1365 (545) | .003 |
| Prothrombin conversion 1 pM TF | |||
| Total prothrombin converted, nM | 1050 (350) | 1313 (532) | NS |
| Maximum prothrombin conversion rate, nM/min | 397 (365) | 480 (173) | NS |
| TG 5 pM TF | |||
| Lag time, min | 2.0 (1.0) | 2.0 (1.3) | NS |
| Time to peak, min | 4.0 (2.0) | 3.0 (2.0) | NS |
| Peak, nM | 340 (58) | 395 (125) | .026 |
| ETP, nM × min | 1130 (145) | 1410 (740) | .001 |
| Inhibition of peak by TM, % | 11.0 (9.0) | 5.5 (9.5) | .048 |
| Prothrombin conversion 5 pM TF | |||
| Total prothrombin converted, nM | 1149 (384) | 1355 (702) | .023 |
| Maximum prothrombin conversion rate, nM/min | 895 (390) | 999 (421) | .041 |
| Inhibition of maximum prothrombin conversion rate by TM, % | 10.2 (20.4) | 6.5 (3.0) | NS |
| Thrombin decay capacity, min−1 | 0.72 (0.28) | 0.65 (0.17) | NS |
| Parameter . | No thrombosis . | Thrombosis . | P . |
|---|---|---|---|
| TG 1 pM TF | |||
| Lag time, min | 4.0 (4.0) | 4.0 (2.3) | NS |
| Time to peak, min | 8.0 (4.0) | 8.0 (2.3) | NS |
| Peak, nM | 238 (133) | 284 (93) | NS |
| ETP, nM × min | 1131 (212) | 1365 (545) | .003 |
| Prothrombin conversion 1 pM TF | |||
| Total prothrombin converted, nM | 1050 (350) | 1313 (532) | NS |
| Maximum prothrombin conversion rate, nM/min | 397 (365) | 480 (173) | NS |
| TG 5 pM TF | |||
| Lag time, min | 2.0 (1.0) | 2.0 (1.3) | NS |
| Time to peak, min | 4.0 (2.0) | 3.0 (2.0) | NS |
| Peak, nM | 340 (58) | 395 (125) | .026 |
| ETP, nM × min | 1130 (145) | 1410 (740) | .001 |
| Inhibition of peak by TM, % | 11.0 (9.0) | 5.5 (9.5) | .048 |
| Prothrombin conversion 5 pM TF | |||
| Total prothrombin converted, nM | 1149 (384) | 1355 (702) | .023 |
| Maximum prothrombin conversion rate, nM/min | 895 (390) | 999 (421) | .041 |
| Inhibition of maximum prothrombin conversion rate by TM, % | 10.2 (20.4) | 6.5 (3.0) | NS |
| Thrombin decay capacity, min−1 | 0.72 (0.28) | 0.65 (0.17) | NS |
NS, not significant.