Multivariate analysis of outcomes for patients with malignant disease
| Effect . | Transplant-related mortality . | Relapse . | Treatment failure (1-DFS) . | Overall mortality . | ||||
|---|---|---|---|---|---|---|---|---|
| RR (95% CI) . | P . | RR (95% CI) . | P . | RR (95% CI) . | P . | RR (95% CI) . | P . | |
| Conditioning regimen | .46 | .15 | .12 | .008 | ||||
| BuCy | 1 | 1 | 1 | 1 | ||||
| BuFlu | 1.2 (0.8-1.9) | 1.2 (0.9-1.6) | 1.2 (1-1.5) | 1.4 (1.1-1.8) | ||||
| Age, y | <.001 | .0002 | ||||||
| 0-9 | 1 | 1 | ||||||
| 10-18 | 2.5 (1.6-3.9) | 0.6 (0.5-0.8) | ||||||
| Sex | .044 | |||||||
| Male | 1 | |||||||
| Female | 0.7 (0.4-1) | |||||||
| Donor type | .0002 | .019 | .006 | |||||
| HLA-identical sibling | 1 | 1 | 1 | |||||
| 8/8 unrelated | 1.85 (1.2-2.8) | 1.2 (1-1.5) | 1.3 (1-1.6) | |||||
| 7/8 unrelated | 2.74 (1.7-4.5) | 1.5 (1.1-2) | 1.6 (1.2-2.2) | |||||
| Disease status | <.001 | <.001 | <.001 | |||||
| Early | 1 | 1 | 1 | |||||
| Intermediate | 1.3 (1-1.8) | 1.2 (0.9-1.6) | 1.3 (1-1.7) | |||||
| Advanced | 2.5 (1.9-3.4) | 2.1 (1.6-2.7) | 2.3 (1.7-3) | |||||
| Unknown | 0.9 (0.6-1.4) | 1 (0.7-1.3) | 0.9 (0.6-1.2) | |||||
| Effect . | Transplant-related mortality . | Relapse . | Treatment failure (1-DFS) . | Overall mortality . | ||||
|---|---|---|---|---|---|---|---|---|
| RR (95% CI) . | P . | RR (95% CI) . | P . | RR (95% CI) . | P . | RR (95% CI) . | P . | |
| Conditioning regimen | .46 | .15 | .12 | .008 | ||||
| BuCy | 1 | 1 | 1 | 1 | ||||
| BuFlu | 1.2 (0.8-1.9) | 1.2 (0.9-1.6) | 1.2 (1-1.5) | 1.4 (1.1-1.8) | ||||
| Age, y | <.001 | .0002 | ||||||
| 0-9 | 1 | 1 | ||||||
| 10-18 | 2.5 (1.6-3.9) | 0.6 (0.5-0.8) | ||||||
| Sex | .044 | |||||||
| Male | 1 | |||||||
| Female | 0.7 (0.4-1) | |||||||
| Donor type | .0002 | .019 | .006 | |||||
| HLA-identical sibling | 1 | 1 | 1 | |||||
| 8/8 unrelated | 1.85 (1.2-2.8) | 1.2 (1-1.5) | 1.3 (1-1.6) | |||||
| 7/8 unrelated | 2.74 (1.7-4.5) | 1.5 (1.1-2) | 1.6 (1.2-2.2) | |||||
| Disease status | <.001 | <.001 | <.001 | |||||
| Early | 1 | 1 | 1 | |||||
| Intermediate | 1.3 (1-1.8) | 1.2 (0.9-1.6) | 1.3 (1-1.7) | |||||
| Advanced | 2.5 (1.9-3.4) | 2.1 (1.6-2.7) | 2.3 (1.7-3) | |||||
| Unknown | 0.9 (0.6-1.4) | 1 (0.7-1.3) | 0.9 (0.6-1.2) | |||||
CI, confidence interval.