Table 1. Primary (diagnostic), PDX T-ALL... | American Society of Hematology

Table 1.

Primary (diagnostic), PDX T-ALL samples and cell lines analyzed and their maturation stage

Sample	Sample type	Blast frequency	EGIL classification	Subgroup	IL7R-JAK-STAT mutation*	JAK-STAT constitutive activation?
T-ALL #01	Primary	90	T-II	TAL/LMO	IL7R wt	n.d.
T-ALL #02	Primary	90	T-III	TLX	IL7R wt	n.d.
T-ALL #03	Primary	87	T-II	n.d.	IL7R wt	n.d.
T-ALL #04	Primary	96	T-IV	n.d.	IL7R wt	n.d.
T-ALL #05	PDX	90	T-II	n.d	IL7R wt	No
T-ALL #06	PDX	85	T-III	TAL/LMO	IL7R wt	No
TAIL7	Cell line	100	T-II	TAL/LMO	IL7R wt	No
HPB-ALL	Cell line	100	T-III	TLX	IL7R wt	No
					JAK1 E966V†
					JAK1 Del(966-989)†

Sample	Sample type	Blast frequency	EGIL classification	Subgroup	IL7R-JAK-STAT mutation*	JAK-STAT constitutive activation?
T-ALL #01	Primary	90	T-II	TAL/LMO	IL7R wt	n.d.
T-ALL #02	Primary	90	T-III	TLX	IL7R wt	n.d.
T-ALL #03	Primary	87	T-II	n.d.	IL7R wt	n.d.
T-ALL #04	Primary	96	T-IV	n.d.	IL7R wt	n.d.
T-ALL #05	PDX	90	T-II	n.d	IL7R wt	No
T-ALL #06	PDX	85	T-III	TAL/LMO	IL7R wt	No
TAIL7	Cell line	100	T-II	TAL/LMO	IL7R wt	No
HPB-ALL	Cell line	100	T-III	TLX	IL7R wt	No
					JAK1 E966V†
					JAK1 Del(966-989)†

European Group for the Immunological Characterization of Leukemias (EGIL) classification⁹⁴: Pro-T (T-I), CD7⁺, cytoplasmic CD3⁺; Pre-T (T-II), CD7⁺, CD2⁺, and/or CD5⁺, cytoplasmic CD3⁺; Cortical-T (T-III), CD1a⁺, cytoplasmic or surface CD3⁺; Mature-T (T-IV), CD1a⁻, surface CD3⁺.

n.d., not determined; LMO, LIM domain only; TAL, T-cell acute lymphocytic leukemia; TLX, T-cell leukemia homeobox; wt, wild-type.

Indicated only genes for which mutational status is known.

†

Mutations do not confer constitutive activity.⁹⁵

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