Population characteristics and regression analysis of VWF levels in the healthy control cohort
| Variable . | Median (IQR) . | c.2365A>G . | c.2385T>C . | ||
|---|---|---|---|---|---|
| Coefficient β (95% CI) . | P . | Coefficient β (95% CI) . | P . | ||
| VWF:Ag, n = 1156 | 97 IU/dL (75, 121) | 7.184 (4.380 to 9.988) | <.001 | 6.986 (4.173 to 9.799) | <.001 |
| VWF:RCo, n = 1155 | 87 IU/dL (65, 113) | 2.215 (−1.721 to 6.151) | .270 | 1.744 (−2.173 to 5.661) | .382 |
| FVIII:C, n = 1161 | 101 IU/dL (77, 127) | 1.112 (−2.477 to 4.701) | .543 | 0.719 (−2.846 to 4.284) | .692 |
| VWF:CB, n = 239 | 80 IU/dL (46, 119) | 0.748 (−10.754 to 12.250) | .898 | 0.178 (−11.097 to 11.454) | .975 |
| VWFpp, n = 389 | 118 IU/dL (104, 135) | 1.172 (−2.674 to 5.018) | .549 | 0.897 (−2.922 to 4.716) | .644 |
| VWFpp/VWF:Ag, n = 387* | 1.24 (1.05, 1.48) | −0.060 (−0.114 to −0.006) | .030 | −0.056 (−0.111 to −0.002) | .043 |
| VWF:FVIIIB, n = 181† | 1.09 (0.98, 1.20) | 0.011 (−0.027 to 0.050) | .563 | 0.013 (−0.026 to 0.051) | .520 |
| Variable . | Median (IQR) . | c.2365A>G . | c.2385T>C . | ||
|---|---|---|---|---|---|
| Coefficient β (95% CI) . | P . | Coefficient β (95% CI) . | P . | ||
| VWF:Ag, n = 1156 | 97 IU/dL (75, 121) | 7.184 (4.380 to 9.988) | <.001 | 6.986 (4.173 to 9.799) | <.001 |
| VWF:RCo, n = 1155 | 87 IU/dL (65, 113) | 2.215 (−1.721 to 6.151) | .270 | 1.744 (−2.173 to 5.661) | .382 |
| FVIII:C, n = 1161 | 101 IU/dL (77, 127) | 1.112 (−2.477 to 4.701) | .543 | 0.719 (−2.846 to 4.284) | .692 |
| VWF:CB, n = 239 | 80 IU/dL (46, 119) | 0.748 (−10.754 to 12.250) | .898 | 0.178 (−11.097 to 11.454) | .975 |
| VWFpp, n = 389 | 118 IU/dL (104, 135) | 1.172 (−2.674 to 5.018) | .549 | 0.897 (−2.922 to 4.716) | .644 |
| VWFpp/VWF:Ag, n = 387* | 1.24 (1.05, 1.48) | −0.060 (−0.114 to −0.006) | .030 | −0.056 (−0.111 to −0.002) | .043 |
| VWF:FVIIIB, n = 181† | 1.09 (0.98, 1.20) | 0.011 (−0.027 to 0.050) | .563 | 0.013 (−0.026 to 0.051) | .520 |
ABO blood group data were available for n = 1124 (n = 481 [42.8%] blood group O).
CI, confidence interval; IQR, interquartile range.
n = 387 (1 individual was excluded from analyses because he or she was classified as an outlier [mean + 3 standard deviations]).
n = 181 of 1166 healthy control individuals (median age, 39 years [range, 4-100]; n = 497 [42.6%] male).