Iron studies of Tfrc+/L645R and Tfrc+/R654H mice after iron (dextran) treatment
| . | Mean ± SD . | ||
|---|---|---|---|
| WT . | Tfrc+/L645R . | Tfrc+/R654H . | |
| Serum Tf, g/L | 9.33 ± 2.44 | 8.22 ± 0.55 | 8.23 ± 3.90 |
| Serum ferritin, μg/L | 3427 ± 445 | 3220 ± 315 | 3939 ± 567 |
| RBC ferritin, μg/L | 148.2 ± 3.68 | 27.80 ± 7.9* | 38.64 ± 5.63* |
| Serum iron, μmol/L | 83.90 ± 9.91 | 77.03 ± 17.4 | 78.80 ± 2.59 |
| TIBC, μmol/L | 89.06 ± 12.1 | 79.04 ± 21.4 | 86.73 ± 15.6 |
| Tf saturation, % | 71.28 ± 15.1 | 64.2 ± 19.8 | 82.37 ± 19.8 |
| Liver iron, nmol/kg | 2.81 ± 0.73 | 3.72 ± 1.37 | 2.69 ± 0.54 |
| MCV, fL | 48.0 v 2.5 | 39.5 ± 1.5* | 35.7 ± 1.6* |
| MCH, pg | 14.7 ± 0.42 | 12.4 ± 0.51* | 11.2 ± 0.25* |
| . | Mean ± SD . | ||
|---|---|---|---|
| WT . | Tfrc+/L645R . | Tfrc+/R654H . | |
| Serum Tf, g/L | 9.33 ± 2.44 | 8.22 ± 0.55 | 8.23 ± 3.90 |
| Serum ferritin, μg/L | 3427 ± 445 | 3220 ± 315 | 3939 ± 567 |
| RBC ferritin, μg/L | 148.2 ± 3.68 | 27.80 ± 7.9* | 38.64 ± 5.63* |
| Serum iron, μmol/L | 83.90 ± 9.91 | 77.03 ± 17.4 | 78.80 ± 2.59 |
| TIBC, μmol/L | 89.06 ± 12.1 | 79.04 ± 21.4 | 86.73 ± 15.6 |
| Tf saturation, % | 71.28 ± 15.1 | 64.2 ± 19.8 | 82.37 ± 19.8 |
| Liver iron, nmol/kg | 2.81 ± 0.73 | 3.72 ± 1.37 | 2.69 ± 0.54 |
| MCV, fL | 48.0 v 2.5 | 39.5 ± 1.5* | 35.7 ± 1.6* |
| MCH, pg | 14.7 ± 0.42 | 12.4 ± 0.51* | 11.2 ± 0.25* |
Blood and tissue iron parameters obtained from 10-week-old WT, RBC6 (+/L645R), and RBC21 (+/R654H) mice, 3 weeks after a single intraperitoneal injection of iron dextran. Two-tailed Student t test was used to compare values with the WT.
P < .05.