DLT: neuropsychiatric toxicity
| Valproate dose, mg/kg per day . | N . | Hallucinations grade 1 . | Confusion . | Somnolence grade 1-2 . | |
|---|---|---|---|---|---|
| Grade 1-2 . | Grade 3 . | ||||
| 30 | 3 | — | — | 0 | — |
| 60 | 20 | — | 2 | 0 | 1 |
| 80 | 3 | — | — | 0 | — |
| 100 | 6 | 5* | 6 | 1 | 6 |
| 120 | 1 | — | 1 | 1 | 2 |
| Valproate dose, mg/kg per day . | N . | Hallucinations grade 1 . | Confusion . | Somnolence grade 1-2 . | |
|---|---|---|---|---|---|
| Grade 1-2 . | Grade 3 . | ||||
| 30 | 3 | — | — | 0 | — |
| 60 | 20 | — | 2 | 0 | 1 |
| 80 | 3 | — | — | 0 | — |
| 100 | 6 | 5* | 6 | 1 | 6 |
| 120 | 1 | — | 1 | 1 | 2 |
Grading according to CTCAE v4.03.
All hallucinations were observed in the same patient.