Potency (IC50 in nanograms per milliliter) of CLL1-D212 and CLL1-PBD ADCs in various AML cell lines
| Cell line . | CLL1-D212 . | IgG-D212 . | CLL1-PBD . | IgG-PBD . |
|---|---|---|---|---|
| ADC, IC50, ng/mL . | ||||
| HL60 | 1.7 | 615 | 0.6 | 588 |
| OCI-AML2 | 0.6 | 230 | 0.2 | 162 |
| OCI-AML5 | 0.7 | 517 | 0.5 | 580 |
| OCI-AML5/CLL1 KO | 650 | 804 | 869 | 897 |
| OCI-M1 | 1535 | 2979 | 477 | 1173 |
| Namo-1 | 328 | 1184 | 136 | 859 |
| Cell line . | CLL1-D212 . | IgG-D212 . | CLL1-PBD . | IgG-PBD . |
|---|---|---|---|---|
| ADC, IC50, ng/mL . | ||||
| HL60 | 1.7 | 615 | 0.6 | 588 |
| OCI-AML2 | 0.6 | 230 | 0.2 | 162 |
| OCI-AML5 | 0.7 | 517 | 0.5 | 580 |
| OCI-AML5/CLL1 KO | 650 | 804 | 869 | 897 |
| OCI-M1 | 1535 | 2979 | 477 | 1173 |
| Namo-1 | 328 | 1184 | 136 | 859 |
KO, knockout.